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Article
Open AccessThe memory ameliorating effects of novel N-benzyl pyridine-2-one derivatives on scopolamine-induced cognitive deficits in mice
Alzheimer's disease (AD), the most common form of progressive dementia in the elderly, is a chronic neurological disorder that decreases cognitive ability. Although the underlying cause of AD is yet unknown, o...
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Article
Synthesis, Characterization and Biological Evaluation of Novel Benzimidazole Derivatives against Candida albicans
In heterocyclic chemistry, benzimidazole is recognized as a “privileged structure” due to its association with a wide range of biological activities. In this present research work, we included the synthesis, c...
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Article
Monitoring forest cover changes and its impact on land surface temperature using geospatial technique in Talra Wildlife Sanctuary, Shimla, India
Forest cover change plays a crucial role in impacting the ecological environment, while land surface temperature (LST) serves as a significant indicator for assessing the effects on Earth's climate system. Thi...
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Chapter
Androgen and Oestrogen Signalling Pathways in Prostate Hyperplastic Tissues: Opportunities for Therapeutic Targeting from Multiple Angles
Benign prostatic hyperplasia (BPH), a non-malignant neoplasm in ageing men, is the most frequent cause of urinary flow obstructions at the bladder neck. In addition to the clear evidence of testosterone-dihydr...
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Chapter
Land Use Land Cover Change Detection and Its Impact on Land Surface Temperature of Malana Watershed Kullu, Himachal Pradesh, India
Land Surface Temperature (LST) is an important phenomenon in global warming, forest fire, glacier melting, global environmental change, and human-environment exchanges. In the present study, an attempt has bee...
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Article
Open AccessGnotobiotic evaluation of Dalbergia sissoo genotypes for resistance against Fusarium solani via dual culture set up
Dalbergia sissoo (shisham), an important multipurpose tree native to the Indian subcontinent and also planted in other countries, has been afflicted with large scale mortality in all age groups due to wilt diseas...
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Chapter and Conference Paper
Computer File Signature Analysis Through Hexadecimal Editor Software
Computer file signature is a unique hexadecimal value written to a file header that acts as an identifying feature to identify a file type, as criminals are becoming more and more aware of digitalization these...
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Chapter and Conference Paper
Wideband Band-stop Filter for C-Band and S-Band Applications Using Finite Integration in Time-Domain Technique
A band-stop filter (BSF), which shows the features of large bandwidth, is present in this paper. Changing the arrangement of quarter wavelength associating shapes of ordinary open-stub band-stop filter with th...
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Article
Impact of Carbon Stocks of Anogeissus latifolia on Climate Change and Socioeconomic Development: a Case Study of Garhwal Himalaya, India
The carbon stored as soil organic carbon (SOC) and tree biomass is typically the highest carbon pool of the forest and is impacted by degradation and deforestation. The impact of “C” stocks on climate change a...
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Article
Open AccessAberrant activation of neuronal cell cycle caused by dysregulation of ubiquitin ligase Itch results in neurodegeneration
It is critical for the neuronal cell cycle to remain suppressed in terminally differentiated neurons as its activation results in aberrant cell cycle re-entry that causes neuronal apoptosis (CRNA), which has b...
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Article
Investigation of T-Shaped Compact Dielectric Resonator Antenna for Wideband Application
In this paper, a novel T-shaped compact Dielectric Resonator Antenna (DRA) is proposed for wide band application. The proposed antenna covers C- and X-band. Two different techniques namely partial ground plane...
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Article
Open AccessDiscovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators
In view of the role of sEH (soluble epoxide hydrolase) in hypertension, we have developed a rigorously validated pharmacophore model containing one HBA (Hydrogen Bond Acceptor), two HY (Hydrophobic) and one RA...
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Article
Open AccessRisk factors for stillbirths: how much can a responsive health system prevent?
The stillbirth rate is an indicator of quality of care during pregnancy and delivery. Good quality care is supported by a functional heath system. The objective of this study was to explore the risk factors fo...
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Article
Identification of new insulin growth factor receptor-1 (IGF-1R) inhibitors via exploring ATPas kinase domain of IGF-1R through virtual screening
Insulin growth factor receptor-1 is a trans-membrane tyrosine kinase receptor that mediates the polypeptide protein hormone insulin growth factor-1, responsible for normal function and growth of human cells. T...
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Article
Toxicophore exploration as a screening technology for drug design and discovery: techniques, scope and limitations
Toxicity is a common drawback of newly designed chemotherapeutic agents. With the exception of pharmacophore-induced toxicity (lack of selectivity at higher concentrations of a drug), the toxicity due to chemo...
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Article
A comprehensive review on bioactive fused heterocycles as purine-utilizing enzymes inhibitors
Purine-utilizing enzymes (PUEs) are involved in the control of biological actions of nitrogen-containing bases, purines and pyrimidines, by participating in their catabolism, and this has made them a topic of ...
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Article
Molecular docking and biological evaluation of hydroxy-substituted (Z)-3-benzylideneindolin-2-one chalcones for the lead identification as tyrosinase inhibitors
The increased cases of hyperpigmentation and other related dermatological problems in human beings have led to the development of a number of tyrosinase inhibitors. In the present study, we have used a docking...
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Article
A review on pharmacophoric designs of antiproliferative agents
Past few decades have witnessed the dawn of new diseases in which cancer is a major problem and the race ensued to eradicate cancer by charting out various effective therapeutic regimens. Circumventing resist...
