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Article
Open AccessNetwork analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetes
The COVID-19 pandemic caused by the SARS-CoV-2 virus has greatly affected global health. Emerging evidence suggests a complex interplay between Alzheimer’s disease (AD), diabetes (DM), and COVID-19. Given COVI...
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Article
Novel biocompatible polymer-modified liposome nanoparticles for biomedical applications
The incidence of pulmonary arterial hypertension (PAH) has significantly increased in the past few decades and therefore requires immediate attention. The applications of drug-loaded nano-systems have shown co...
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Article
Open AccessGenomic insights and advanced machine learning: characterizing autism spectrum disorder biomarkers and genetic interactions
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition characterized by altered brain connectivity and function. In this study, we employed advanced bioinformatics and explainable AI to analy...
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Chapter
Polymeric Nanocarriers for the Delivery of Phytoconstituents
In past decades, with the advent of nanotechnology, nanocarriers have been highlighted as promising drug delivery systems for therapeutic, diagnostic, and nutraceutical agents. Based on their chemical nature, ...
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Chapter
Gelatin-based Hydrogels for Drug Delivery: A Recent Update
The flexible functionalization of gelatin provides opportunities for easy and efficient cross-linking as well as combining with other materials (such as metal nanoparticles (MNPs), carbonaceous materials, and ...
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Article
New insights on mode of action of vasorelaxant activity of simvastatin
Simvastatin is a semisynthetic inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and is used extensively to treat atherosclerotic cardiovascular disease. Apart from the lipid-lowering effe...
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Chapter
Transporter Systems and Metabolism at the Blood–Brain Barrier and Blood–CSF Barrier
Neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), are a leading cause of morbidity and mortality. The presence of blood–cerebrospinal flu...
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Article
Moments of Order Statistics from Length-Biased Exponential Distribution and Associated Inference
Dara and Ahmad (Recent advances in moment distribution and their hazard rates, Academic Publishing GmbH KG, Lap Lambert, 2012) proposed the length-biased exponential (LBE) distribution and proved that the LBE ...
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Article
Role of curcumin in ameliorating hypertension and associated conditions: a mechanistic insight
Curcumin, belongs to the curcuminoid family, is a natural phenolic compound, presenting low bioavailability and pleiotropic activity. Since ancient times, curcumin has been in use as food spices and folk remed...
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Article
Open AccessRelationships for Moments of Generalized Order Statistics from Hjorth Distribution and Related Inference
In this paper some recurrence relations satisfied by single and product moments of generalized order statistics from Hjorth distribution have been obtained. Then we use these results to compute the first two m...
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Article
Targeting the Autophagy Specific Lipid Kinase VPS34 for Cancer Treatment: An Integrative Repurposing Strategy
The impact of autophagy on cancer treatment and its corresponding responsiveness has galvanized the scientific community to develop novel inhibitors for cancer treatment. Importantly, the discovery of inhibito...
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Article
Open AccessDistinct metabolic states of a cell guide alternate fates of mutational buffering through altered proteostasis
Metabolic changes alter the cellular milieu; can this also change intracellular protein folding? Since proteostasis can modulate mutational buffering, if change in metabolism has the ability to change protein ...
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Article
Open AccessFlurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model
Ethosomes have been widely used in Transdermal Drug Delivery System (TDDS) as they increase the permeation of drug across the skin.
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Article
Discovery of Therapeutic Lead Molecule Against β-Tubulin Using Computational Approach
Virtual screening strategy was performed against the target β-tubulin to overcome paclitaxel resistance in blood cancer types. In essence, A185T and A248V are two such important mutations frequently observed i...
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Article
Open AccessDiscovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators
In view of the role of sEH (soluble epoxide hydrolase) in hypertension, we have developed a rigorously validated pharmacophore model containing one HBA (Hydrogen Bond Acceptor), two HY (Hydrophobic) and one RA...
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Article
Exploring the impact of F270V mutation in the β-tubulin (Bos Taurus) structure and its function: a computational perspective
Paclitaxel is the most effective chemotherapeutic agent used for the treatment of a broad spectrum of solid tumors. However, observed paclitaxel resistance in clinical trials presents one of the major obstacle...
