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Article
Systematical Evaluation of the Structure-Cardiotoxicity Relationship of 7-Azaindazole-based PI3K Inhibitors Designed by Bioisosteric Approach
A growing concern of cardiotoxicity induced by PI3K inhibitors has raised the requirements to evaluate the structure-cardiotoxicity relationship (SCR) in the development process of novel inhibitors. Based on t...
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Article
Open Accessp53 promotes peroxisomal fatty acid β-oxidation to repress purine biosynthesis and mediate tumor suppression
The metabolic pathways through which p53 functions as a potent tumor suppressor are incompletely understood. Here we report that, by associating with the Vitamin D receptor (VDR), p53 induces numerous genes en...
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Article
Open AccessNo MERS-CoV but positive influenza viruses in returning Hajj pilgrims, China, 2013–2015
There is global health concern that the mass movement of pilgrims to and from Mecca annually could contribute to the international spread of Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In China, a...
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Article
Open AccessRobust inference of the context specific structure and temporal dynamics of gene regulatory network
Response of cells to changing endogenous or exogenous conditions is governed by intricate molecular interactions, or regulatory networks. To lead to appropriate responses, regulatory network should be 1) conte...
