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Article
Effects of different water and nitrogen treatments on greenhouse tomato yield, water use efficiency, and physiological responses
This study aimed to explore how the yield, water use efficiency (WUE), and physiological characteristics of greenhouse-cultivated tomatoes in Northeast China respond to different water and nitrogen treatments ...
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Article
Open AccessFunctional dissection of PRC1 subunits RYBP and YAF2 during neural differentiation of embryonic stem cells
Polycomb repressive complex 1 (PRC1) comprises two different complexes: CBX-containing canonical PRC1 (cPRC1) and RYBP/YAF2-containing variant PRC1 (vPRC1). RYBP-vPRC1 or YAF2-vPRC1 catalyzes H2AK119ub through...
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Article
Open AccessLoss of Dip2b leads to abnormal neural differentiation from mESCs
Disco-interacting protein 2 homolog B is a member of the Dip2 family encoded by the Dip2b gene. Dip2b is widely expressed in neuro-related tissues and is essential in axonal outgrowth during embryogenesis.
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Article
Open AccessGeneration of an mESC model with a human hemophilia B nonsense mutation via CRISPR/Cas9 technology
Hemophilia B is a rare inherited genetic bleeding disorder caused by a deficiency or lack of coagulation factor IX, the gene for which (F9) is located on the X chromosome. Hemophilia B is currently incurable and ...
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Article
Open AccessDownregulation of S100 calcium binding protein A12 inhibits the growth of glioma cells
S100 calcium binding protein A12 (S100A12) is a member of the S100 protein family and is widely expressed in neutrophil and low expressed in lymphocytes and monocyte. However, the role of S100A12 in glioma has...
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Article
Open AccessPCGF5 is required for neural differentiation of embryonic stem cells
Polycomb repressive complex 1 (PRC1) is an important regulator of gene expression and development. PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has ...
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Article
Open AccessGenome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs
Induced pluripotent stem cells can be derived from somatic cells through ectopic expression of transcription factors or chemical cocktails. Chemical iPSCs (C-iPSCs) and OSKM-iPSCs (4F-iPSCs) have been suggeste...
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Article
Open AccessDynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells
Nucleosome positioning and histone modification play a critical role in gene regulation, but their role during reprogramming has not been fully elucidated. Here, we determined the genome-wide nucleosome covera...
