9 Result(s)

Article

Overexpressing lipid raft protein STOML2 modulates the tumor microenvironment via NF-κB signaling in colorectal cancer

Colorectal cancer (CRC) is characterized by a complex tumor inflammatory microenvironment, while angiogenesis and immunosuppression frequently occur concomitantly. However, the exact mechanism that controls an...

Hui Gong, Shao**g Chen, Shuguang Liu, Qianying Hu… in Cellular and Molecular Life Sciences (2024)

Article

An endoplasmic reticulum stress-related signature could robustly predict prognosis and closely associate with response to immunotherapy in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors. Endoplasmic reticulum stress (ERS) plays an essential role in PDAC progression. Here, we aim to identify the ERS-related genes in PD...

Shuguang Liu, Qianying Hu, Zishan **e… in Journal of Cancer Research and Clinical On… (2023)

Article

An alternative CTCF isoform antagonizes canonical CTCF occupancy and changes chromatin architecture to promote apoptosis

CTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of mammalian genomes. Previous studies have mainly fo...

Jiao Li, Kaimeng Huang, Gongcheng Hu, Isaac A. Babarinde, Yaoyi Li… in Nature Communications (2019)

Article

Silver-catalyzed remote Csp³-H functionalization of aliphatic alcohols

Aliphatic alcohols are common and bulk chemicals in organic synthesis. The site-selective functionalization of non-activated aliphatic alcohols is attractive but challenging. Herein, we report a silver-catalyz...

Yuchao Zhu, Kaimeng Huang, Jun Pan, Xu Qiu, **ao Luo, Qixue Qin… in Nature Communications (2018)

Article

PCGF5 is required for neural differentiation of embryonic stem cells

Polycomb repressive complex 1 (PRC1) is an important regulator of gene expression and development. PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has ...

Mingze Yao, Xueke Zhou, Jiajian Zhou, Shixin Gong, Gongcheng Hu… in Nature Communications (2018)

Article

Identification of critical base pairs required for CTCF binding in motif M1 and M2

Wufeng Li, Li** Shang, Kaimeng Huang, Jiao Li, Zhibin Wang, Hongjie Yao in Protein & Cell (2017)

Article

Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells

Nucleosome positioning and histone modification play a critical role in gene regulation, but their role during reprogramming has not been fully elucidated. Here, we determined the genome-wide nucleosome covera...

Kaimeng Huang, **aobai Zhang, Jiejun Shi, Mingze Yao, Jiannan Lin… in Scientific Reports (2015)

Article

Correction: Corrigendum: The oncogene c-Jun impedes somatic cell reprogramming

Nat. Cell Biol. 17, 856–867 (2015); published online 22 June 2015; corrected after print 10 August 2015 In the version of this Article originally published, panels from Fig. 8e were mistakenly reproduced as Fi...

**g Liu, Qingkai Han, Tianran Peng, Meixiu Peng, Bei Wei… in Nature Cell Biology (2015)