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Article
Open AccessMicrocurrent wave alleviates mouse intracranial arterial dolichoectasia development
Intracranial arterial dolichoectasia (IADE) is associated with the interaction of hypertension and inflammation, and microcurrent can be effective in hypertension. Therefore, this study aimed to investigate th...
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Article
Open AccessAcid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease
Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular...
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Article
Open AccessImmunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease
Acid sphingomyelinase (ASM) has been implicated in neurodegenerative disease pathology, including Alzheimer’s disease (AD). However, the specific role of plasma ASM in promoting these pathologies is poorly und...
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Article
Open AccessAlpha-beta transition induced by C18-conjugation of polyalanine and its implication in aqueous solution behavior of poly(ethylene glycol)-polyalanine block copolymers
The aqueous solution behavior of thermosensitive PEG-PA block copolymers as well as secondary structure of PA is expected to significantly change through modification of the hydrophobic PA by long chain alkyl ...
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Article
Open AccessN-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer’s disease
Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons in a model of Alzheimer’s disease (AD). However, the mechanism underlying this activity ...
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Article
Open AccessPotential therapeutic target for aging and age-related neurodegenerative diseases: the role of acid sphingomyelinase
Aging, which is associated with age-related changes in physiological processes, is the most significant risk factor for the development and progression of neurodegenerative diseases, including Alzheimer’s dise...
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Article
Establishment of an electroporation-mediated gene delivery system in porcine spermatogonial stem cells
Spermatogonial stem cells (SSCs) are a useful tool for the generation of genetically modified transgenic sperm. As a result, the transfer of specific genes into the cytoplasm of SSCs is crucial for the success...
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Article
Open AccessMesenchymal stem cell 3D encapsulation technologies for biomimetic microenvironment in tissue regeneration
Mesenchymal stem cell (MSC) encapsulation technique has long been emerged in tissue engineering as it plays an important role in implantation of stem cells to regenerate a damaged tissue. MSC encapsulation pro...
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Article
Open AccessNeuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer’s Disease
Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer’s disease (AD), the underlying mechanism remains to be explored. Here we demonstrate that ...
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Article
Processing plastics from ASR/ESR waste: separation of poly vinyl chloride (PVC) by froth flotation after microwave-assisted surface modification
The feasibility of the selective surface hydrophilization of poly vinyl chloride (PVC) using microwave treatment to facilitate the separation of PVC via froth flotation from automobile shredder residue (ASR) a...
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Article
Emulating Host-Microbiome Ecosystem of Human Gastrointestinal Tract in Vitro
The human gut microbiome performs prodigious physiological functions such as production of microbial metabolites, modulation of nutrient digestion and drug metabolism, control of immune system, and prevention ...
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Chapter and Conference Paper
A Survey of Change of Scale Formulas on an Analogue of Wiener Space
Let (C[0, t], w φ ) denote an analogue of Wiener space, that is, the space of real-valued continuous paths on [0, t]. The measure w φ
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Article
Highly efficient reprogramming and characterization of induced pluripotent stem cells by using a microwell array
Reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) enables the possibility of generating patient-specific cells. However, the low efficiency issue associated with iPSCs generation h...
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Article
Open AccessStudy on chemotaxis and chemokinesis of bone marrow-derived mesenchymal stem cells in hydrogel-based 3D microfluidic devices
Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitm...
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Article
Open AccessPathological roles of the VEGF/SphK pathway in Niemann–Pick type C neurons
Sphingosine is a major storage compound in Niemann–Pick type C disease (NP–C), although the pathological role(s) of this accumulation have not been fully characterized. Here we found that sphingosine kinase (S...
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Article
Development of a high-yield technique to isolate spermatogonial stem cells from porcine testes
To date, the methods available for isolating spermatogonial stem cells (SSCs) from porcine testicular cells have a low efficiency of cell separating. Therefore, we tried to develop a novel isolation technique ...
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Article
Changes of isoflavone profiles in Cheonggukjang with Lentinus edodes
Cheonggukjang, a traditional soy food, was prepared with addition of Lentinus edodes powder at 0, 5, and 10% (w/w), and the distribution of isoflavones were analyzed by high performance liquid ch...
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Article
Volatile distribution in garlic (Allium sativum L.) by solid phase microextraction (SPME) with different processing conditions
Treatments of autoclaving, high temperature aging (aged-black garlic), crushing, and roasting at 100, 150, and 200°C were applied to alter the volatile profiles of garlic (Allium sativum L.). Headspace volatiles ...
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Article
Analysis of Bacterial and Fungal Communities in Japanese- and Chinese-Fermented Soybean Pastes Using Nested PCR–DGGE
The microbial diversity of Japanese- and Chinese-fermented soybean pastes was investigated using nested PCR–denaturing gradient gel electrophoresis (DGGE). Five Japanese-fermented soybean paste samples and thr...
