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Article
Open AccessAcid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease
Over the past decade, numerous studies have highlighted the importance of acid sphingomyelinase (ASM) in disease treatment in humans. This enzyme functions primarily to generate ceramide, maintain the cellular...
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Article
Open AccessImmunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease
Acid sphingomyelinase (ASM) has been implicated in neurodegenerative disease pathology, including Alzheimer’s disease (AD). However, the specific role of plasma ASM in promoting these pathologies is poorly und...
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Article
Open AccessDetermination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells
A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...
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Article
Open AccessA novel single-port laparoscopic operation for colorectal cancer with transanal specimen extraction: a comparative study
Extension of a single incision for the purpose of specimen extraction in single-port laparoscopic surgery (SPLS) can undermine the merits of SPLS, either by hurting cosmesis or by increasing wound morbidity.
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Article
Successful total shift from multiport to single-port laparoscopic surgery in low anterior resection of colorectal cancer
To assess the possibility of using single-port low anterior resection (LAR) in place of conventional laparoscopic LAR.
