-
Article
Open AccessRandomized phase II study of daily and alternate-day administration of S-1 for advanced gastric cancer (JFMC43-1003)
Although S-1 based chemotherapy for patients with advanced gastric cancer has generally been accepted in Japan, discontinuations of treatment have been reported due to grade 3 or more adverse events. The prese...
-
Article
Decrease in ICAM-1 expression on gastric cancer cells is correlated with lymph node metastasis
Lymph node metastasis is a frequent type of metastasis in patients with gastric cancer. The mechanisms responsible for this type of metastasis, however, are not clearly understood. We hypothesize that the imm...
-
Article
Estrogen receptor status is the most important prognostic factor in breast cancer with ten or more positive lymph nodes
Background. In breast cancer, the prognosis worsens with increasing lymph node involvement, and aggressive therapies may prolong survival in patients with advanced breast cancer. However, there are sub-populatio...
-
Article
p53 Protein overexpression as a predictor of the response to chemotherapy in gastric cancer
This study was performed to evaluate p53 overexpression as a predictor of the response to chemotherapy of patients with gastric cancer. The subjects comprised 20 patients with Stage IV gastric cancer and three...
-
Article
Establishment of lymph node metastatic model for human gastric cancer in nude mice and analysis of factors associated with metastasis
The actual mechanisms responsible for lymph node metastasis in gastric cancer are still unclear. To investigate the mechanisms of lymph node metastasis in gastric cancer, we established a lymph node metastatic...
-
Article
Adhesion polypeptides are useful for the prevention of peritoneal dissemination of gastric cancer
We examined the effect of adhesion polypeptides on the adhesion and invasiveness of gastric cancer cell lines. We previously reported the establishment of an extensively peritoneal-seeding cell line, OCUM-2MD3...
-
Article
Diagnostic Potential and Pitfalls of Ultrasound-guided Fine-Needle Aspiration Cytology for Breast Lesions
-
Article
Identification and characterization of motility stimulating factor secreted from pancreatic cancer cells: role in tumor invasion and metastasis
Cell motility is an important factor in the process of invasion and metastasis of tumor. In this study, the relationship between cell motility and experimental metastatic potential was examined using two human...
-
Article
Establishment of a cisplatin-resistant gastric carcinoma cell line OCUM-2M/DDP
A cis-diamminedichloroplatinum (CDDP)-resistant scirrhous gastric cancer cell line, OCUM-2M/DDP, was established by chronic exposure of cells of the parent scirrhous gastric cancer cell line, OCUM-2M, to CDDP at...
-
Article
Peritoneal metastatic model for human scirrhous gastric carcinoma in nude mice
We established a peritoneal-metastatic model for scirrhous gastric carcinoma. Peritoneal metastasis had developed after intraperitoneal inoculation of OCUM-2MD3 cells in nude mice. This cell line was derived f...
-
Article
Mucoepidermoid carcinoma of the pancreas: Report of a case
We present herein the case of a 64-year-old man diagnosed as having a mucoepidermoid carcinoma of the pancreas. The tumor originated in the tail of the pancreas and invaded the spleen, left adrenal gland, left...
-
Article
A case of primary Hodgkin's disease of the stomach
A case of primary Hodgkin's disease, a lymphocyte-predominant entity, occurring in the stomach is described. The patient was a 37-year-old man who complained of general fatigue. Endoscopic biopsy revealed gast...
-
Article
A flow cytometric bromodeoxyuridine/DNA analysis for cytokinetics of the pancreatic cancer cell line capan-2 after irradiation
The cytokinetics of the human pancreatic adenocarcinoma cell line Capan-2 were analyzed by a bromodeoxyuridine (BrdUrd)/DNA analysis with flow cytometry (FCM). The reproducibility of data was shown to be super...
-
Chapter and Conference Paper
Immunohistochemical Study of PCNA (Proliferating Cell Nuclear Antigen) in Gastric Cancer with Special Reference to Progression and Prognosis
We investigated the correlation between tumor’s proliferative activity and progression of gastric carcinoma using immunohistochemical staining with PC10 monoclonal antibody recognizing Proliferating Cell Nucle...
-
Chapter and Conference Paper
Role of O-Linked Oligosaccharides and Sialic Acids in Pancreatic Cancer Cell Interaction with Extracellular Matrix
Human pancreatic cancer cell, SW1990 produce high mucin which have predominantly O-linked oligosaccharides. SW1990 cell also have high levels of in vitro invasiveness and high in vivo liver metastatic potentia...
-
Chapter and Conference Paper
c-myc Gene Expression in Primary Gastric Cancer
In this-study, we investigated the expression of c-myc mRNA in 48 patients with primary gastric cancer (51 lesions) and 11 metastatic lymph node lesions. Thirty-five (68.6%)of the primary lesions demonstrated c-m...
-
Chapter and Conference Paper
Study of a Synthesized New Carbohydrate Antigen in Gastro-Intestinal Cancers
In this study, a novel monoclonal antibody (Flα-75) directed to a carbohydrate antigen (Flα), which was chemically synthesized, was raised and the expression of Flα was evaluated in gastric and colon cancers. ...
-
Chapter and Conference Paper
Adhesion of Human Cancer Cells to Vascular Endothelium Mediated by a Carbohydrate Antigen, SPan-1
A new human extrahepatic bile duct carcinoma cell line (OCUCh-LM1) and a new human colon cancer cell line (OCUC-LM1) were established from respective hepatic metastases in our laboratory. Cells of both lineage...
-
Chapter and Conference Paper
Immunohistological Expression of Pancreatic Cancer Associated Mucin Antigen and Radioimmunodetection in Pancreatic Cancer
Nd2 is a murine monoclonal antibody produced against a mucin fraction purified from pancreatic cancer cell line SW1990 and the antigen recognized has been clarified to be a noncirculating antigen. In this stud...
-
Chapter and Conference Paper
Biodistribution of Monoclonal Antibody Nd2 Following Administration of Several Routes
Nd2 is a murine monoclonal antibody (MAb) directed against purified mucin of human pancreatic cancer cell line SW1990. In this study we investigated the differences of Nd2 tumor accumulation rate with routes o...
