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Article
Usefulness of laparoscopic surgery for colorectal perforation: a single-center retrospective cohort study
This study aimed to determine the safety and efficacy of laparoscopic surgery in patients with colorectal perforation owing to a significant lack of evidence in this field.
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Article
Pneumothorax during lenvatinib treatment for hepatocellular carcinoma with lung metastasis
Lenvatinib is an inhibitor of tyrosine kinases, such as vascular endothelial growth factor receptor and fibroblast growth factor receptor, and was first approved for use in thyroid cancer in 2015 in Japan. Add...
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Article
Early response to erythropoiesis-stimulating agents in non-dialysis chronic kidney disease patients
Renal anemia complicated with chronic kidney disease is usually treated with erythropoiesis-stimulating agents (ESAs). However, few studies have compared the early response of hemoglobin (Hb) to different kind...
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Article
Prospective randomized study of the tolerability and efficacy of combination therapy for hypertensive chronic kidney disease: results of the PROTECT-CKD study
We conducted a randomized, open-label trial to determine which of the antihypertensive drugs was most beneficial for CKD patients with hypertension in spite of treatment with an angiotensin receptor blocker (A...
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Article
Responsiveness to erythropoiesis-stimulating agents and renal survival in patients with chronic kidney disease
Renal anemia of chronic kidney disease (CKD) is generally treated by erythropoiesis-stimulating agents (ESAs). However, there are individual differences in patients’ responsiveness to ESA, which may affect the...
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Article
Effects of three kinds of erythropoiesis-stimulating agents on renal anemia in Japanese non-dialysis chronic kidney disease patients
Erythropoiesis-stimulating agents (ESAs) are standard therapy for chronic kidney disease (CKD) patients with renal anemia. However, few studies have compared the effects of different ESAs on anemia in identica...
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Article
Open AccessLower serum sodium level predicts higher risk of infection-related hospitalization in maintenance hemodialysis patients: an observational cohort study
Hyponatremia is associated with increased mortality in chronic kidney disease with and without end-stage renal disease (ESRD). Increasing evidence suggests that hyponatremia is not only a marker of severe unde...
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Article
Open AccessBaseline characteristics and prevalence of cardiovascular disease in newly visiting or referred chronic kidney disease patients to nephrology centers in Japan: a prospective cohort study
About 39,000 patients were newly prescribed renal replacement therapy in Japan in 2011, resulting in a total of more than 300,000 patients being treated with dialysis. This high prevalence of treated end stage...
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Article
The impact of hyporesponsiveness to erythropoietin-stimulating agents on time-dependent mortality risk among CKD stage 5D patients: a single-center cohort study
Hyporesponsiveness to a large dose of erythropoietin-stimulating agents (ESA) could increase mortality risk among chronic kidney disease patients. This study aimed to assess a safe dose of ESA and the impact o...
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Article
Effects of sevelamer hydrochloride on mortality, lipid abnormality and arterial stiffness in hemodialyzed patients: a propensity-matched observational study
Cause-and-effect associations between sevelamer hydrochloride (HCl) and mortality have yet to be clarified. The effects of sevelamer HCl on mortality, lipid abnormality and arterial stiffness were examined in ...
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Article
Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis
Anemia is a common complication of patients with chronic kidney disease (CKD), which not only lowers their quality of life but also potentially causes cardiovascular diseases such as congestive heart failure a...
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Article
Expression of bone type 1 PTH receptor in rats with chronic renal failure
Some researchers have speculated that a decrease in bone type 1 PTH receptor (PTH1R) may be among the causes of “skeletal resistance” in chronic renal failure (CRF). Indeed, the down-regulation of PTH1R mRNA h...
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Article
Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments
Vasopressin-induced trafficking of aquaporin-2 (AQP2) water channels in kidney collecting duct cells is critical to regulate the urine concentration. To better understand the mechanism of subcellular trafficki...
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Article
Interim evidence of the renoprotective effect of the angiotensin II receptor antagonist losartan versus the calcium channel blocker amlodipine in patients with chronic kidney disease and hypertension: a report of the Japanese Losartan Therapy Intended for Global Renal Protection in Hypertensive Patients (JLIGHT) Study
Background. Insufficiency of renal function and high blood pressure influence each other and eventually result in life-threatening endstage renal disease. It has been proposed that protei...
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Chapter
Molecular Cloning of a New Aquaporin Superfamily in Mammals
Currently, aquaporins (AQPs) are divided into two subfamilies: AQP1 group and AQP3 group. AQP1 group is water-selective AQP and has 6 members in mammals: AQPO, AQP1, AQP2, AQP4, AQP5, AQP6. They share similar ...
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Chapter
Molecular biology of aquaporins
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Article
Mitogen-activated protein kinase cascade and cell cycle-related genes in the kidney
Recent studies have shown that mitogen-activated protein kinase (MAPK) consists of at least 3 subfamilies, including the classical MAPK, stress-activated protein kinase/c-Jun N-terminal kinase, and p38 kinase....
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Chapter
Cell pH Regulation in Collecting Tubules
We measured the single cell pH of principal cells (PC) and intercalated cells (IC) in the outer stripe of the outer medullary collecting duct (OMCDo) of the rabbit using fluorescence ratio imaging.
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Article
Pre-steady-state analysis of the turn-on and turn-off of water permeability in the kidney collecting tubule
Water transport across the mammalian collecting tubule is regulated by vasopressin-dependent water channel insertion into and retrieval from the cell apical membrane. The time course of osmotic water permeabil...
