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  1. Article

    Open Access

    Cytoprotective IgG antibodies in sera from a subset of patients with AQP4-IgG seropositive neuromyelitis optica spectrum disorder

    Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system. Most NMOSD patients are seropositive for immunoglobulin G (IgG) autoantibodies against astroc...

    Lukmanee Tradtrantip, Michael R. Yeaman, A. S. Verkman in Scientific Reports (2021)

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  2. Article

    Open Access

    Clobetasol promotes remyelination in a mouse model of neuromyelitis optica

    Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can produce marked neurological deficit. Current NMO therapies include immunosuppressants, plasma exchange...

    **aoming Yao, Tao Su, A. S. Verkman in Acta Neuropathologica Communications (2016)

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  3. No Access

    Article

    Aquaporin-3-mediated hydrogen peroxide transport is required for NF-κB signalling in keratinocytes and development of psoriasis

    Aquaporin 3 (AQP3), a water/glycerol channel protein, has been found to transport hydrogen peroxide (H2O2). Here, we show that H2O2, imported via AQP3, is involved in nuclear factor-κB (NF-κB) signalling in kerat...

    Mariko Hara-Chikuma, Hiroki Satooka, Sachiko Watanabe… in Nature Communications (2015)

  4. No Access

    Article

    Unique neuromyelitis optica pathology produced in naïve rats by intracerebral administration of NMO-IgG

    Animal models of neuromyelitis optica (NMO) are needed for elucidation of disease mechanisms and for testing new therapeutics. Prior animal models of NMO involved administration of human anti-aquaporin-4 immun...

    Nithi Asavapanumas, Julien Ratelade, A. S. Verkman in Acta Neuropathologica (2014)

  5. No Access

    Article

    Involvement of antibody-dependent cell-mediated cytotoxicity in inflammatory demyelination in a mouse model of neuromyelitis optica

    Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system that can cause paralysis and blindness. The pathogenesis of NMO involves binding of immunoglobulin G autoantibo...

    Julien Ratelade, Nithi Asavapanumas, Alanna M. Ritchie… in Acta Neuropathologica (2013)

  6. No Access

    Article

    C1q-targeted monoclonal antibody prevents complement-dependent cytotoxicity and neuropathology in in vitro and mouse models of neuromyelitis optica

    Neuromyelitis optica (NMO) is an autoimmune disorder with inflammatory demyelinating lesions in the central nervous system, particularly in the spinal cord and optic nerve. NMO pathogenesis is thought to invol...

    Puay-Wah Phuan, Hua Zhang, Nithi Asavapanumas, Michael Leviten… in Acta Neuropathologica (2013)

  7. No Access

    Article

    Neuromyelitis optica IgG and natural killer cells produce NMO lesions in mice without myelin loss

    The pathogenesis of neuromyelitis optica (NMO) involves targeting of NMO-immunoglobulin G (NMO-IgG) to aquaporin-4 (AQP4) on astrocytes in the central nervous system. Prior work provided evidence for complemen...

    Julien Ratelade, Hua Zhang, Samira Saadoun, Jeffrey L. Bennett… in Acta Neuropathologica (2012)

  8. No Access

    Article

    The expression of differentiation markers in aquaporin-3 deficient epidermis

    Aquaporin-3 (AQP3) is a water/glycerol transporting protein expressed strongly at the plasma membrane of keratinocytes. There is evidence for involvement of AQP3-facilitated water and glycerol transport in ker...

    Mariko Hara-Chikuma, Kenzo Takahashi… in Archives of Dermatological Research (2009)

  9. No Access

    Article

    Aquaporins and cell migration

    Aquaporin (AQP) water channels are expressed primarily in cell plasma membranes. In this paper, we review recent evidence that AQPs facilitate cell migration. AQP-dependent cell migration has been found in a v...

    M. C. Papadopoulos, S. Saadoun… in Pflügers Archiv - European Journal of Phys… (2008)

  10. No Access

    Article

    Aquaporins—new players in cancer biology

    The aquaporins (AQPs) are small, integral-membrane proteins that selectively transport water across cell plasma membranes. A subset of AQPs, the aquaglyceroporins, also transport glycerol. AQPs are strongly ex...

    A. S. Verkman, Mariko Hara-Chikuma, Marios C. Papadopoulos in Journal of Molecular Medicine (2008)

  11. No Access

    Article

    Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing

    Healing of skin wounds is a multi-step process involving the migration and proliferation of basal keratinocytes in epidermis, which strongly express the water/glycerol-transporting protein aquaporin-3 (AQP3). ...

    Mariko Hara-Chikuma, A. S. Verkman in Journal of Molecular Medicine (2008)

  12. No Access

    Reference Work Entry In depth

    Aquaporins in the Central Nervous System

    The aquaporins (AQPs) are a family of water channels expressed in plasma membrane of many cell types. At least three aquaporins are expressed in the central nervous system (CNS): AQP1 in choroid plexus, AQP4 i...

    M. C. Papadopoulos, S. Saadoun… in Handbook of Neurochemistry and Molecular N… (2007)

  13. No Access

    Article

    Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins

    A subclass of aquaporin (AQP) water channels, termed aquaglyceroporins, are also able to transport glycerol and perhaps urea and other small solutes. Although extensive data exist on the physiological roles of...

    M. Hara-Chikuma, A. S. Verkman in Cellular and Molecular Life Sciences CMLS (2006)

  14. No Access

    Article

    Slowed diffusion in tumors revealed by microfiberoptic epifluorescence photobleaching

    It has not been possible to measure diffusion deep in solid tissues such as tumors because of the limited light penetration of conventional optical techniques. Here we report a microfiberoptic epifluorescence ...

    Jay R Thiagarajah, Jung Kyung Kim, Mazin Magzoub, A S Verkman in Nature Methods (2006)

  15. No Access

    Article

    Aquaporins and CFTR in Ocular Epithelial Fluid Transport

    Aquaporins (AQPs) and the cystic fibrosis transmembrane conductance regulator (CFTR) provide the molecular routes for transport of water and chloride, respectively, through many epithelial tissues. In ocular e...

    M.H. Levin, A.S. Verkman in The Journal of Membrane Biology (2006)

  16. No Access

    Chapter and Conference Paper

    Increased seizure duration in mice lacking aquaporin-4 water channels

    Aquaporins are intrinsic membrane proteins involved in water transport in fluid-transporting tissues. In the brain, aquaporin-4 (AQP4) is expressed widely by glial cells, but its function is unclear. Extensive...

    D. K. Binder, X. Yao, A. S. Verkman, G. T. Manley in Brain Edema XIII (2006)

  17. No Access

    Article

    K+ waves in brain cortex visualized using a long-wavelength K+-sensing fluorescent indicator

    We synthesized a water-soluble, long-wavelength K+ sensor, TAC-Red, consisting of triazacryptand coupled to 3,6-bis(dimethylamino)xanthylium, whose fluorescence increased 14-fold at 0–50 mM K+ with K+-to-Na+ sele...

    Prashant Padmawar, **aoming Yao, Orin Bloch, Geoffrey T Manley… in Nature Methods (2005)

  18. No Access

    Article

    Novel roles of aquaporins revealed by phenotype analysis of knockout mice

    The aquaporins (AQPs) are small integral membrane proteins that transport water and in some cases small solutes such as glycerol. Physiological roles of the ten or more mammalian AQPs have been proposed based ...

    A. S. Verkman in Reviews of Physiology, Biochemistry and Pharmacology (2005)

  19. No Access

    Article

    Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability1,2,3. The role of AQP1 in endothelial cell function is unknown. Here we s...

    Samira Saadoun, Marios C. Papadopoulos, Mariko Hara-Chikuma, A. S. Verkman in Nature (2005)

  20. No Access

    Chapter

    Novel roles of aquaporins revealed by phenotype analysis of knockout mice

    The aquaporins (AQPs) are small integral membrane proteins that transport water and in some cases small solutes such as glycerol. Physiological roles of the ten or more mammalian AQPs have been proposed based ...

    A. S. Verkman in Reviews of Physiology Biochemistry and Pharmacology (2005)

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