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Article
Open AccessAdding epitope compatibility to deceased donor kidney allocation criteria: recommendations from a pan-Canadian online public deliberation
The widening supply–demand imbalance for kidneys necessitates finding ways to reduce rejection and improve transplant outcomes. Human leukocyte antigen (HLA) epitope compatibility between donor and recipient m...
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Article
Open AccessPublic values and guiding principles for implementing epitope compatibility in kidney transplantation allocation criteria: results from a Canadian online public deliberation
Epitope compatibility in deceased donor kidney allocation is an emerging area of precision medicine (PM), seeking to improve compatibility between donor kidneys to transplant candidates in the hope of avoiding...
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Article
Open AccessLINE-1 ORF1p as a candidate biomarker in high grade serous ovarian carcinoma
Long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p) expression is a common feature of many cancer types, including high-grade serous ovarian carcinoma (HGSOC). Here, we report that ORF1p ...
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Article
Open AccessDevelo** Psychologically Compelling Understanding of the Involvement of Humans in Research
Research conducted on humans has a long history of ethical protections, with the Nuremberg trials in 1945 and 1946 triggering stronger protection across most jurisdictions. While there have been many reorienta...
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Article
Health Technology Assessment as Part of a Broader Process for Priority Setting and Resource Allocation
Over the last two decades, economic evaluation of health technologies has developed enormously, affirming its importance within the pursuit of efficiency in the management of health care systems. One concern t...
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Article
Correction to: Multiple diversity concepts and their ethical-epistemic implications
The original version of this article unfortunately contained a mistake. The fourth author’s name is Bianca Crewe, not Bianca Crew. The original article has been corrected.
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Article
Open AccessMultiple diversity concepts and their ethical-epistemic implications
A concept of diversity is an understanding of what makes a group diverse that may be applicable in a variety of contexts. We distinguish three diversity concepts, show that each can be found in discussions of ...
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Open AccessEngaging the Canadian public on reimbursement decision-making for drugs for rare diseases: a national online survey
Funding of drugs for rare diseases (DRDs) requires decisions that balance fairness for all individuals within the healthcare system with compassion for affected individuals. Our study objective was to conduct ...
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Article
Biofuel production using food
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Pesticides Applied Worldwide to Combat Pests
A major concern in agriculture is that more than half of all food production (including food in storage) is being lost to pests despite more than 3 million tons of pesticides being utilized worldwide. Losses o...
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Environmental and Economic Benefits of Reducing Pesticide Use
Pesticides cause serious public health problems and considerable damage to agricultural and natural ecosystems. We confirm previous reports that it is feasible to reduce pesticide use by 50 % or more. The Swed...
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Environmental and Economic Costs of the Application of Pesticides Primarily in the United States
An obvious need for an updated and comprehensive study prompted this investigation of the complex of environmental and economic costs resulting from the nation’s dependence on pesticides. Included in this asse...
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An Environmental, Energetic and Economic Comparison of Organic and Conventional Farming Systems
Various organic technologies have been utilized for about 6,000 years to make agriculture sustainable while at the same time conserving soil, water, energy and biological resources. Benefits of organic technol...
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Chapter
Opening Pandora’s Box: Process and Paradox in the Federalism of Political Identity
The Berlin Wall fell in November 1989 signalling the end of the Cold War and ushering in—or so it seemed—a new dawn in both European and world politics. The implications of its impact were as colossal as they ...
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Article
Nuclear War Investigation Related to a Limited Nuclear Battle with Emphasis on Agricultural Impacts in the United States
A limited battle involving the nuclear arsenals of India and Pakistan would have significant climatic impacts upon agricultural crop production in the United States; corn, soybeans, and winter wheat yields wou...
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Small amounts of pesticides reaching target insects
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Multinational Federalism in Multinational Federation
In a seminal paper titled ‘Federalism and the Making of Nations’ first published in an edited volume of essays in 1955, Kenneth Wheare reflected upon the limits and possibilities of using the federal idea as a...
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Article
A pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Rational strategies to prioritize candidate biomarkers should save resources and accelerate progress in diagnostics development. Addona et al. integrate proteomics into a pipeline for biomarker validation and use...
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Article
Open AccessSequencing the salmon genome: A deliberative public engagement
Salmon genomics is an emerging field that represents a convergence between socially important scientific innovation and a politically volatile topic of significant interest to the public. These factors provide...
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Article
Open AccessEvolutionary concepts in biobanking - the BC BioLibrary
Medical research to improve health care faces a major problem in the relatively limited availability of adequately annotated and collected biospecimens. This limitation is creating a growing gap between the pa...
