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Article
27-Hydroxycholesterol inhibits trophoblast fusion during placenta development by activating PI3K/AKT/mTOR signaling pathway
Trophoblast cell syncytialization is essential for placental and fetal development. Abnormal trophoblast cell fusion leads to pregnancy pathologies, such as preeclampsia (PE), intrauterine growth restriction (...
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Article
Open AccessC3N nanodots inhibits Aβ peptides aggregation pathogenic path in Alzheimer’s disease
Despite the accumulating evidence linking the development of Alzheimer’s disease (AD) to the aggregation of Aβ peptides and the emergence of Aβ oligomers, the FDA has approved very few anti-aggregation-based t...
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Article
Chiral carbon dots from glucose by room temperature alkali-assisted synthesis for electrocatalytic oxidation of tryptophan enantiomers
Chiral catalysis is one of the most direct and effective approach to obtain pure optical enantiomers. Chiral carbon dots (CDs) as carbon-based chiral catalysts show great potential in chiral catalysis. Herein,...
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Article
Open AccessRAD21 is the core subunit of the cohesin complex involved in directing genome organization
The ring-shaped cohesin complex is an important factor for the formation of chromatin loops and topologically associating domains (TADs) by loop extrusion. However, the regulation of association between cohesi...
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Article
Open AccessLncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing
Nasopharyngeal carcinoma (NPC) is a common head and neck malignant with a high incidence in Southern China. Genetic aberrations play a vital role in the pathogenesis, progression and prognosis of NPC. In the p...
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Article
How to divide diverse biomass samples to build near-infrared spectroscopy models for gross calorific value
Near-infrared spectroscopy models for gross calorific value (GCV) were developed for different subsets of woody and herbaceous samples to screen subsets based on the biomass type for optimal models. A woody su...
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Article
Open AccessAmmonium tetrathiomolybdate triggers autophagy-dependent NRF2 activation in vascular endothelial cells
Ammonium tetrathiomolybdate (TTM) is a copper chelator in clinical trials for treatment of Wilson’s disease, tumors and other diseases. In the current study, we innovatively discovered that TTM is a novel NRF2...
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Article
Open AccessRoot-order-associated variations in fine-root decomposition and their effects on soil in a subtropical evergreen forest
Despite the importance of root decomposition in predicting ecosystem responses to future climate change, the effects of branch order on root decomposition and the feedback to soil still remains poorly understo...
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Article
Open AccessReciprocal regulation of NRF2 by autophagy and ubiquitin–proteasome modulates vascular endothelial injury induced by copper oxide nanoparticles
NRF2 is the key antioxidant molecule to maintain redox homeostasis, however the intrinsic mechanisms of NRF2 activation in the context of nanoparticles (NPs) exposure remain unclear. In this study, we revealed...
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Article
Open AccessPINK1/TAX1BP1-directed mitophagy attenuates vascular endothelial injury induced by copper oxide nanoparticles
Copper oxide nanoparticles (CuONPs) are widely used metal oxide NPs owing to their excellent physical–chemical properties. Circulation translocation of CuONPs after inhalation leads to vascular endothelial inj...
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Article
Open AccessTranscription-coupled structural dynamics of topologically associating domains regulate replication origin efficiency
Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle. Origin choice is linked to cell growth, differentiation, and replication st...
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Article
Open AccessA molecular architectural design that promises potent antimicrobial activity against multidrug-resistant pathogens
Addressing the devastating threat of drug-resistant pathogens requires the discovery of new antibiotics with advanced action mechanisms and/or novel strategies for drug design. Herein, from a biophysical persp...
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Article
An innovative strategy for improving the performance of forward osmosis membrane: stripe-like Turing structure constructed by introducing hydrophilic polyvinylpyrrolidone
Improving the performance of forward osmosis (FO) membranes has always been moving forward. Here we fabricate the novel Turing structures in the active layer (AL) of thin film composite (TFC) membrane through ...
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Article
Open AccessTMEM175 mediates Lysosomal function and participates in neuronal injury induced by cerebral ischemia-reperfusion
As the main organelles for the clearance of damaged proteins and damaged organelles, the function of lysosomes is crucial for maintaining the intracellular homeostasis of long-lived neurons. A stable acidic en...
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Article
Open AccessGenome-wide identification of CNGC genes in Chinese jujube (Ziziphus jujuba Mill.) and ZjCNGC2 mediated signalling cascades in response to cold stress
Cyclic nucleotide gated channels (CNGCs) play multifaceted roles in plant physiological processes, especially with respect to signalling processes, plant development, and responses to environmental stresses. H...
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Open AccessAuthor Correction: A novel quantitative PCR mediated by high-fidelity DNA polymerase
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Size Reduction and Calcium Release of Fish Bone Particles During Nanomilling as Affected by Bone Structure
Three types of fish bones including fish skull, rib, and backbone were cooked at 120 °C for 20 min to remove tissues and impurities. The fish bones were minced and ground into microscaled particles before trea...
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Article
Open AccessA novel quantitative PCR mediated by high-fidelity DNA polymerase
The biggest challenge for accurate diagnosis of viral infectious disease is the high genetic variability of involved viruses, which affects amplification efficiency and results in low sensitivity and narrow sp...
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Article
Open AccessCharacterising the bacterial microbiota across the gastrointestinal tracts of dairy cattle: membership and potential function
The bacterial community composition and function in the gastrointestinal tracts (GITs) of dairy cattle is very important, since it can influence milk production and host health. However, our understanding of b...
