25 Result(s)

Article

Prevention of post-operative delirium using an overnight infusion of dexmedetomidine in patients undergoing cardiac surgery: a pragmatic, randomized, double-blind, placebo-controlled trial

After cardiac surgery, post-operative delirium (PoD) is acknowledged to have a significant negative impact on patient outcome. To date, there is no valuable and specific treatment for PoD. Critically ill patie...

Olivier Huet, Thomas Gargadennec, Jean-Ferréol Oilleau, Bertrand Rozec… in Critical Care (2024)

Article

Prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis of non-pharmacological interventions

Cardiac surgery-associated acute kidney injury (CSA-AKI) is frequent. While two network meta-analyses assessed the impact of pharmacological interventions to prevent CSA-AKI, none focused on non-pharmacologica...

Geoffroy Hariri, Lucie Collet, Lucie Duarte, Guillaume L. Martin… in Critical Care (2023)

Article

Association between combination antibiotic therapy as opposed as monotherapy and outcomes of ICU patients with Pseudomonas aeruginosa ventilator-associated pneumonia: an ancillary study of the iDIAPASON trial

The optimal treatment duration and the nature of regimen of antibiotics (monotherapy or combination therapy) for Pseudomonas aeruginosa ventilator‑associated pneumonia (PA-VAP) remain debated. The aim of this stu...

Arnaud Foucrier, Thomas Dessalle, Sophie Tuffet, Laura Federici… in Critical Care (2023)

Article

Levosimendan in patients undergoing extracorporeal membrane oxygenation after cardiac surgery: an emulated target trial using observational data

Retrospective cohorts have suggested that levosimendan may facilitate the weaning of veno-arterial extracorporeal membrane oxygenation (VA-ECMO). We therefore studied this clinical question by emulating a rand...

Julien Massol, Noémie Simon-Tillaux, Joanna Tohme, Geoffroy Hariri… in Critical Care (2023)

Article

Post-cardiac surgery fungal mediastinitis: clinical features, pathogens and outcome

The occurrence of mediastinitis after cardiac surgery remains a rare and severe complication associated with poor outcomes. Whereas bacterial mediastinitis have been largely described, little is known about th...

Geoffroy Hariri, Mathieu Genoud, Vincent Bruckert, Samuel Chosidow… in Critical Care (2023)

Article

Using a multiomics approach to unravel a septic shock specific signature in skeletal muscle

Sepsis is defined as a dysregulated host response to infection leading to organs failure. Among them, sepsis induces skeletal muscle (SM) alterations that contribute to acquired-weakness in critically ill pati...

Baptiste Duceau, Michael Blatzer, Jean Bardon, Thibault Chaze… in Scientific Reports (2022)

Article

Correction to: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial

Adrien Bouglé, Sophie Tuffet, Laura Federici, Marc Leone… in Intensive Care Medicine (2022)

Article

Usefulness of lung ultrasound for early detection of hospital-acquired pneumonia in cardiac critically ill patients on venoarterial extracorporeal membrane oxygenation

Hospital-acquired pneumonia (HAP) is the most common and severe complication in patients treated with venoarterial extracorporeal membrane oxygenation (VA ECMO) and its diagnosis remains challenging. Nothing i...

Jean Pasqueron, Pauline Dureau, Gauthier Arcile… in Annals of Intensive Care (2022)

Article

Low-dose corticosteroid therapy for cardiogenic shock in adults (COCCA): study protocol for a randomized controlled trial

Cardiogenic shock (CS) is a life-threatening condition characterized by circulatory insufficiency caused by an acute dysfunction of the heart pump. The pathophysiological approach to CS has recently been enric...

Armand Mekontso Dessap, François Bagate, Clément Delmas… in Trials (2022)

Article

Predictive risk factors for postoperative pneumonia after heart transplantation

Pneumonia is a frequent complication in patients undergoing heart transplantation (HTx) that increases morbidity and mortality in this population. Nevertheless, the risk factors for postoperative pneumonia (PO...

Charles Vidal, Romain Pasqualotto, Arthur James, Pauline Dureau… in BMC Anesthesiology (2020)

Article

Outcomes of Stenotrophomonas maltophilia hospital-acquired pneumonia in intensive care unit: a nationwide retrospective study

There is little descriptive data on Stenotrophomonas maltophilia hospital-acquired pneumonia (HAP) in critically ill patients. The optimal modalities of antimicrobial therapy remain to be determined. Our objectiv...

Philippe Guerci, Hugo Bellut, Mokhtar Mokhtari, Julie Gaudefroy… in Critical Care (2019)

Article

The effect of local anesthetic continuous wound infusion for the prevention of postoperative pneumonia after on-pump cardiac surgery with sternotomy: the STERNOCAT randomized clinical trial

Postoperative pain after cardiac surgery, exacerbated by cough and sternal mobilization, limits clearance of bronchopulmonary secretions and may predispose to postoperative pneumonia. In this study, we tested ...

Julien Amour, Bernard Cholley, Alexandre Ouattara, Dan Longrois… in Intensive Care Medicine (2019)

Article

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool

Skeletal muscle has the capacity to adapt to environmental changes and regenerate upon injury. To study these processes, most experimental methods use quantification of parameters obtained from images of immun...

Alicia Mayeuf-Louchart, David Hardy, Quentin Thorel, Pascal Roux… in Skeletal Muscle (2018)

Article

Impact of the duration of antibiotics on clinical events in patients with Pseudomonas aeruginosa ventilator-associated pneumonia: study protocol for a randomized controlled study

Ventilator-associated pneumonia (VAP) accounts for 25% of infections in intensive care units. Compared to a long duration (LD) of antibiotic therapy, a short duration (SD) has a comparable clinical efficacy wi...

Adrien Bouglé, Arnaud Foucrier, Hervé Dupont, Philippe Montravers… in Trials (2017)

Article

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Chtara Kamilia, Kais Regaieg, Najeh Baccouch, Hedi Chelly… in Annals of Intensive Care (2017)

Article

Proceedings of Réanimation 2017, the French Intensive Care Society International Congress

Wulfran Bougouin, Eloi Marijon, Benjamin Planquette… in Annals of Intensive Care (2017)

Article

Muscle regeneration after sepsis

Severe critical illness is often complicated by intensive care unit-acquired weakness (ICU-AW), which is associated with increased ICU and post-ICU mortality, delayed weaning from mechanical ventilation and lo...

Adrien Bouglé, Pierre Rocheteau, Tarek Sharshar, Fabrice Chrétien in Critical Care (2016)