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Article
Open AccessEffect of Luseogliflozin, a Sodium-Glucose Cotransporter 2 Inhibitor, and Dipeptidyl-Peptidase 4 Inhibitors on the Quality-of-Life and Treatment Satisfaction of Patients With Type 2 Diabetes Mellitus: A Subanalysis of a Multicenter, Open-Label, Randomized-Controlled Trial (J-SELECT Study)
The effects of dipeptidyl peptidase-4 inhibitors (DPP-4is) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) on quality of life (QOL) and treatment satisfaction have not been directly compared. This sub-...
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Article
Open AccessOverall Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitor Luseogliflozin Versus Dipeptidyl-Peptidase 4 Inhibitors: Multicenter, Open-Label, Randomized-Controlled Trial (J-SELECT study)
Evidence of a direct comparison between dipeptidyl-peptidase 4 inhibitors (DPP-4is) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) remains lacking, and no clear treatment strategy or rationale has bee...
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Article
Open AccessInfluences of various parameters on shear stiffness of bolted joints subjected to shear load
Parameters which affect shear stiffness characteristics of bolted joints subjected to shear load should be elucidated in order to design mechanical structures for functionality focusing not only on their stren...
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Article
Open AccessAuthor Correction: Cryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility
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Article
Open AccessA Myb enhancer-guided analysis of basophil and mast cell differentiation
The transcription factor MYB is a crucial regulator of hematopoietic stem and progenitor cells. However, the nature of lineage-specific enhancer usage of the Myb gene is largely unknown. We identify the Myb −68 e...
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Article
Open AccessStructure of the IscB–ωRNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9
Transposon-encoded IscB family proteins are RNA-guided nucleases in the OMEGA (obligate mobile element-guided activity) system, and likely ancestors of the RNA-guided nuclease Cas9 in the type II CRISPR-Cas ad...
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Article
Open AccessCryo-EM structures of thermostabilized prestin provide mechanistic insights underlying outer hair cell electromotility
Outer hair cell elecromotility, driven by prestin, is essential for mammalian cochlear amplification. Here, we report the cryo-EM structures of thermostabilized prestin (PresTS), complexed with chloride, sulfate,...
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Chapter
Synthetic Perspective on Prehistoric Hunter-Gatherer Adaptations and Landscape Change in Northern Japan
Arguments pertaining to the peopling of America have long addressed the proposed late Pleistocene human migration from Northeast Asia. In this context, the northern part of the Japanese archipelago has receive...
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Article
Open AccessMechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
Human ether-à-go-go-related gene potassium channel 1 (hERG) is a voltage-gated potassium channel, the voltage-sensing domain (VSD) of which is targeted by a gating-modifier toxin, APETx1. APETx1 is a 42-residue p...
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Article
Effect of tasteless calorie-free gum chewing before meal on postprandial plasma glucose, insulin, glucagon, and gastrointestinal hormones in Japanese men without diagnosed glucose metabolism disorder: a pilot randomized crossover trial
This pilot study aimed to examine the effect of pre-meal tasteless calorie-free gum chewing on post-meal blood levels of glucose, insulin, glucagon, and gastrointestinal hormones. This was an open-label, rando...
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Article
Open AccessAuthor Correction: Structural basis for delta cell paracrine regulation in pancreatic islets
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessStructural basis for delta cell paracrine regulation in pancreatic islets
Little is known about the role of islet delta cells in regulating blood glucose homeostasis in vivo. Delta cells are important paracrine regulators of beta cell and alpha cell secretory activity, however the s...
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Article
Open AccessModulating the Work Function of Graphene by Pulsed Plasma Aided Controlled Chlorination
Chlorine on graphene (G) matrices was doped by pulsed plasma stimulation on graphite electrode submerged in organochlorine solvents (CH2Cl2, CHCl3, CCl4). The study of work function by Kelvin probe force microsco...
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Chapter and Conference Paper
FPGA-Based Parallel Pattern Matching
To protect IoT (Internet of Things) nodes against cyber attacks, NIDS (Network-based Intrusion Detection System) is becoming important. On future high-speed networks, NIDS needs to be high-speed hardware and p...
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Chapter and Conference Paper
Difference of Chirality of the Electron Between Enantiomers of H \(_2\) X \(_2\)
The integrated chirality density of H \(_2\) 2 X \(_2\) 2 molecules is studied in viewpoints of the internal torque for the electron spin. Since the density is proportional to the zeta pote...
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Article
In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe
Retinal hypoxia plays a crucial role in ocular neovascular diseases, such as diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusion. Fluorescein angiography is useful for identifying ...
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Article
Open AccessStructural basis for dynamic mechanism of nitrate/nitrite antiport by NarK
NarK belongs to the nitrate/nitrite porter (NNP) family in the major facilitator superfamily (MFS) and plays a central role in nitrate uptake across the membrane in diverse organisms, including archaea, bacter...
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Chapter and Conference Paper
Spin Torque and Zeta Force in Allene-Type Molecules
The spin torque, the zeta force, and the zeta potential, which are significant quantities to describe the local picture of spin dynamics, are studied by using allene-type molecules (C3H4 and C3H2Li2) in their sta...
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Chapter and Conference Paper
Grid Computing Supporting System on ITBL Project
Prototype of the middleware for Grid project promoted by national institutes in Japan has been developed. Key technologies that are indispensable for construction of virtual organization were already implement...
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Article
Estimation of polyunsaturated fatty acid content in lipids of aquatic organisms using thin-layer chromatography on a plain silica gel plate
We have designed a rapid method for the separation of polyunsaturated fatty acids (PUFA, ≥trienes) from non-PUFA, and for estimation of total amounts of PUFA in lipids of aquatic organisms. Lipids from thirty-...
