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Article
Open AccessRenal tubular function and morphology revealed in kidney without labeling using three-dimensional dynamic optical coherence tomography
Renal tubule has distinct metabolic features and functional activity that may be altered during kidney disease. In this paper, we present label-free functional activity imaging of renal tubule in normal and ob...
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Article
Subretinal injection in mice to study retinal physiology and disease
Subretinal injection (SRI) is a widely used technique in retinal research and can be used to deliver nucleic acids, small molecules, macromolecules, viruses, cells or biomaterials such as nanobeads. Here we de...
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Article
Open AccessLabel-free functional and structural imaging of liver microvascular complex in mice by Jones matrix optical coherence tomography
We demonstrate label-free imaging of the functional and structural properties of microvascular complex in mice liver. The imaging was performed by a custom-built Jones-matrix based polarization sensitive optic...
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Article
Open AccessNucleoside reverse transcriptase inhibitors and Kamuvudines inhibit amyloid-β induced retinal pigmented epithelium degeneration
Nonfibrillar amyloid-β oligomers (AβOs) are a major component of drusen, the sub-retinal pigmented epithelium (RPE) extracellular deposits characteristic of age-related macular degeneration (AMD), a common cau...
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Chapter
Anterior Segment OCT: An Overview
Anterior segment optical coherence tomography (AS-OCT) originally derived from posterior segment OCT. By changing the wavelength of the light source to a longer range, 1,000–1,300 nm, which is suboptimal for p...
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Chapter
Anterior Segment OCT: Polarization-Sensitive OCT
The conventional intensity-oriented OCT utilizes scattering information to evaluate morphological features of biological tissues. The new generation of OCT, polarization-sensitive OCT (PS-OCT), is capable of m...
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Article
Open AccessRepurposing anti-inflammasome NRTIs for improving insulin sensitivity and reducing type 2 diabetes development
Innate immune signaling through the NLRP3 inflammasome is activated by multiple diabetes-related stressors, but whether targeting the inflammasome is beneficial for diabetes is still unclear. Nucleoside revers...
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Article
Comparison of anterior segment and lens biometric measurements in patients with cataract
This study was performed to compare anterior ocular biometric measurements of deep-range swept-source anterior segment optical coherence tomography (AS-OCT) (CASIA2) versus short-range swept-source AS-OCT (CAS...
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Article
Open AccessComparison of intensity, phase retardation, and local birefringence images for filtering blebs using polarization-sensitive optical coherence tomography
Polarization-sensitive optical coherence tomography (PS-OCT) allows the recording of depth-resolved polarimetric measurements. It has been reported that phase retardation and local birefringence images can non...
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Article
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Degeneration of the retinal pigment epithelium is a hallmark of geographic atrophy, a type of age-related macular degeneration. Kerur et al. show that this degeneration results from a multistep pathway in which m...
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Article
Functional visual acuity in patients with successfully treated amblyopia: a pilot study
The aim of this study was to use conventional visual acuity measurements to quantify the functional visual acuity (FVA) in eyes with successfully treated amblyopia, and to compare the findings with those for c...
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Article
In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe
Retinal hypoxia plays a crucial role in ocular neovascular diseases, such as diabetic retinopathy, retinopathy of prematurity, and retinal vascular occlusion. Fluorescein angiography is useful for identifying ...
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Article
Oxidative stress retards vascular development before neural degeneration occurs in retinal degeneration rd1 mice
To investigate the role of reactive oxygen species (ROS) in retinal development during the early postnatal stage of rd1 mice.
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Chapter
Neuroprotection by Endothelial Progenitor Cells for Retinal Degeneration
Retinitis pigmentosa is an inherited eye disorder that leads to profound vision loss and is characterized by retinal neuron degeneration, fundus pigment changes, optic disc atrophy, and vasculature attenuation...
