4 Result(s)

Article

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Microglia are highly plastic immune cells which exist in a continuum of activation states. By sha** the function of oligodendrocyte precursor cells (OPCs), the brain cells which differentiate to myelin-formi...

Marta Lombardi, Roberta Parolisi, Federica Scaroni… in Acta Neuropathologica (2019)

Article

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. However, the mo...

Ilaria Prada, Martina Gabrielli, Elena Turola, Alessia Iorio… in Acta Neuropathologica (2018)

Article

Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Fingolimod, also known as FTY720, is an analogue of the sphingolipid sphingosine, which has been proved to be neuroprotective in rodent models of Alzheimer’s disease (AD). Several cellular and molecular target...

Pooja Joshi, Martina Gabrielli, Luisa Ponzoni, Silvia Pelucchi… in Scientific Reports (2017)

Article

Active endocannabinoids are secreted on the surface of microglial microvesicles

Martina Gabrielli, Natalia Battista, Loredana Riganti, Ilaria Prada… in SpringerPlus (2015)