4 Result(s)

Article

Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure

Microglia are highly plastic immune cells which exist in a continuum of activation states. By sha** the function of oligodendrocyte precursor cells (OPCs), the brain cells which differentiate to myelin-formi...

Marta Lombardi, Roberta Parolisi, Federica Scaroni… in Acta Neuropathologica (2019)

Article

Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations

Recent evidence indicates synaptic dysfunction as an early mechanism affected in neuroinflammatory diseases, such as multiple sclerosis, which are characterized by chronic microglia activation. However, the mo...

Ilaria Prada, Martina Gabrielli, Elena Turola, Alessia Iorio… in Acta Neuropathologica (2018)

Article

TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice

The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain althoug...

Maria Cristina Marrone, Annunziato Morabito, Michela Giustizieri… in Nature Communications (2017)

Article

Active endocannabinoids are secreted on the surface of microglial microvesicles

Martina Gabrielli, Natalia Battista, Loredana Riganti, Ilaria Prada… in SpringerPlus (2015)