51 Result(s)
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Article
Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-...
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Article
Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments
Lineage tracing is key to study the fate of individual cells and their progeny especially in developmental biology. To conduct these studies, we aimed to establish a reproducible model of CDH in the most commo...
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Article
Open AccessCourse of an unplanned and unexpected pregnancy in a 39 year-old patient with Complex bladder extrophy: a case report
With improved operative techniques pregnancy rates have been rising in patients with anomalies of the extrophy-epispadias-complex, including also female patients with bladder extrophy. Specific risks around pr...
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Article
Open AccessReal-time MRI: a new tool of radiologic imaging in small children
Real-time MRI (rt-MRI) in children is a new imaging technique that combines the advantages of US — at frame rates of up to 50 images per second — with the quality and features of MRI. Although still subject of...
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Article
Open AccessDevelopment of an international core outcome set for treatment trials in necrotizing enterocolitis—a study protocol
Necrotizing enterocolitis (NEC) is the most lethal disease of the gastrointestinal tract of preterm infants. New and existing management strategies need clinical evaluation. Large heterogeneity exists in the s...
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Article
Testicular descent revisited: a micro-computed tomography study in fetal rats
There is a long history of research dealing with the embryology of the testicular descent. However, important aspects like the role of the gubernaculum and the development of the processus vaginalis peritonei ...
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Article
Open AccessPectus excavatum in motion: dynamic evaluation using real-time MRI
The breathing phase for the determination of thoracic indices in patients with pectus excavatum is not standardized. The aim of this study was to identify the best period for reliable assessments of morphologi...
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Article
Langzeitmorbidität und Transition von Kindern mit Ösophagusatresie
Fast täglich wird in Deutschland ein Kind mit Ösophagusatresie (ÖA) geboren. Die Gesamtüberlebensrate hat sich in den letzten Jahrzehnten signifikant verbessert. Auch nach einer erfolgreichen Operation haben P...
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Article
Tenascin C is dysregulated in hypoplastic lungs of miR-200b−/− mice
We previously demonstrated that absence of miR-200b results in abnormal lung development in congenital diaphragmatic hernia due to imbalance between epithelial and mesenchymal cells. Tenascin C is a highly con...
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Article
Musculoskeletal deformities in children with congenital thoracic malformations: a population-based cohort study
It is unclear if musculoskeletal deformities observed in patients with congenital diaphragmatic hernia (CDH), congenital lung lesion (CLL) and esophageal atresia/tracheoesophageal fistula (EA/TEF) are associat...
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Chapter
Energy Sources in Pediatric MIS Urology
Minimally invasive surgery (MIS) in pediatric urology has developed rapidly in the last 20 years. Almost all conventional abdominal and retroperitoneal urologic procedures have been now performed minimally inv...
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Chapter
Blunt Abdominal Trauma
Trauma is the leading cause of disability and death in children. Pediatric trauma patients present unique clinical challenges as compared to adults, including different mechanisms of injury, physiologic respon...
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Article
Open AccessSurgical treatment of esophageal atresia with lower tracheoesophageal fistula in an extremely preterm infant (510 g, 25 + 5 weeks): a case report
The surgical management of esophageal atresia in extreme-low-birth-weight infants (< 1000 g) is challenging. We report on an extreme-low-birth-weight infant who was extremely preterm (510 g, 25 + 5 weeks) and ...
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Chapter
Necrotizing Enterocolitis (NEC)
(NEC) is the most common lethal gastrointestinal (GI) disease in preterm infants worldwide. It is characterized by severe inflammatory response and intestinal necrosis, and may have a different pathogenesis...
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Chapter
Laparoscopic Thal Fundoplication
Gastroesophageal reflux disease (GERD) especially in neurologically impaired children remains the main indication for anti-reflux surgery in children. Laparoscopic fundoplication is the treatment of choice. Se...
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Chapter
Laparoscopic Pyloromyotomy
Hypertrophic pyloric stenosis is the main reason for nonbilious vomiting in the first 3 months of life and is diagnosed by ultrasound. Laparoscopic pyloromyotomy is the treatment of choice. Its technique, rele...
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Chapter
Laparoscopic Resection of Choledochal Cyst with Hepaticojejunostomy
Choledochal cysts (CDCs) are believed to represent a risk factor for the development of neoplasia; the classical clinical triade is a right upper quadrant mass, associated with pain and jaundice. Therefore the...
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Chapter
Laparoscopic Pyeloplasty
Laparoscopic transabdominal dismembered pyeloplasty for ureteropelvic junction obstruction (UPJO) is effective and safe in infants and children. The indications for laparoscopic pyeloplasty are the same as for...
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Article
Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation
Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are two inborn pathologies of the lung of unknown origin. Alterations of gene expression in airway epithelial cells are...
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Chapter
Laparoscopic Herniorrhaphy
Laparoscopic inguinal hernia repair in children has increased in popularity over the past years. The indications for laparoscopic inguinal hernia repair are the same as for the open approach. Several randomize...
