Skip to main content

4 Result(s)

within Mark W. Pellegrino Remove this filter

and

  1. Article

    Open Access

    Identification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration

    Snakes exhibit extreme intestinal regeneration following months-long fasts that involves unparalleled increases in metabolism, function, and tissue growth, but the specific molecular control of this process is...

    Aundrea K. Westfall, Blair W. Perry, Abu H. M. Kamal, Nicole R. Hales… in BMC Genomics (2022)

    Download PDF (5128 KB) View Article

  2. No Access

    Article

    Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

    In the context of mitochondrial genome heteroplasmy that causes defective oxidative phosphorylation in C. elegans, the ATFS-1-mediated mitochondrial unfolded protein response maintains the deleterious mitochondri...

    Yi-Fan Lin, Anna M. Schulz, Mark W. Pellegrino, Yun Lu, Shai Shaham… in Nature (2016)

  3. Article

    Open Access

    Mitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection

    Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkin...

    Mark W Pellegrino, Cole M Haynes in BMC Biology (2015)

    Download PDF (662 KB) View Article

  4. No Access

    Article

    Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

    A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activat...

    Mark W. Pellegrino, Amrita M. Nargund, Natalia V. Kirienko, Reba Gillis… in Nature (2014)