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Article
Open AccessIdentification of an integrated stress and growth response signaling switch that directs vertebrate intestinal regeneration
Snakes exhibit extreme intestinal regeneration following months-long fasts that involves unparalleled increases in metabolism, function, and tissue growth, but the specific molecular control of this process is...
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Article
Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response
In the context of mitochondrial genome heteroplasmy that causes defective oxidative phosphorylation in C. elegans, the ATFS-1-mediated mitochondrial unfolded protein response maintains the deleterious mitochondri...
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Article
Open AccessMitophagy and the mitochondrial unfolded protein response in neurodegeneration and bacterial infection
Mitochondria are highly dynamic and structurally complex organelles that provide multiple essential metabolic functions. Mitochondrial dysfunction is associated with neurodegenerative conditions such as Parkin...
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Article
Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection
A link between an intracellular stress response, bacterial infection and triggering of the innate immune response is shown in Caenorhabditis elegans; exposure to the pathogen Pseudomonas aeruginosa caused activat...