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within Mark J.S. Kelly Remove this filter Science, Humanities and Social Sciences, multidisciplinary Remove this filter

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  1. No Access

    Article

    Systems-level effects of allosteric perturbations to a model molecular switch

    Molecular switch proteins whose cycling between states is controlled by opposing regulators1,2 are central to biological signal transduction. As switch proteins function within highly connected interaction networ...

    Tina Perica, Christopher J. P. Mathy, Jiewei Xu, Gwendolyn Μ. Jang, Yang Zhang… in Nature (2021)

  2. No Access

    Article

    Histone demethylase KDM5A is regulated by its reader domain through a positive-feedback mechanism

    The retinoblastoma binding protein KDM5A removes methyl marks from lysine 4 of histone H3 (H3K4). Misregulation of KDM5A contributes to the pathogenesis of lung and gastric cancers. In addition to its catalyti...

    Idelisse Ortiz Torres, Kristopher M. Kuchenbecker, Chimno I. Nnadi… in Nature Communications (2015)

  3. No Access

    Article

    The structural basis of yeast prion strain variants

    A comprehensive structural analysis of the complete and unmodified Sup35 prion domain in two distinct infectious conformations is presented. A variety of techniques is used to provide structural details of the...

    Brandon H. Toyama, Mark J. S. Kelly, John D. Gross, Jonathan S. Weissman in Nature (2007)