8 Result(s)

Article

Type I interferon signaling is required for the APOBEC3/Rfv3-dependent neutralizing antibody response but not innate retrovirus restriction

APOBEC3/Rfv3 restricts acute Friend retrovirus (FV) infection and promotes virus-specific neutralizing antibody (NAb) responses. Classical Rfv3 studies utilized FV stocks containing lactate-dehydrogenase eleva...

Bradley S. Barrett, Michael S. Harper, Sean T. Jones, Kejun Guo… in Retrovirology (2017)

Article

Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection

Early HIV-1 infection is characterized by high levels of HIV-1 replication and substantial CD4 T cell depletion in the intestinal mucosa, intestinal epithelial barrier breakdown, and microbial translocation. H...

Stephanie M. Dillon, Eric J. Lee, Andrew M. Donovan, Kejun Guo… in Retrovirology (2016)

Article

Friend retrovirus drives cytotoxic effectors through Toll-like receptor 3

Pathogen recognition drives host defense towards viral infections. Specific groups rather than single members of the protein family of pattern recognition receptors (PRRs) such as membrane spanning Toll-like r...

Kathrin Gibbert, Sandra Francois, Anna M Sigmund, Michael S Harper… in Retrovirology (2014)

Article

Microbial exposure alters HIV-1-induced mucosal CD4⁺ T cell death pathways Ex vivo

Early HIV-1 infection causes massive CD4+ T cell death in the gut and translocation of bacteria into the circulation. However, the programmed cell death (PCD) pathways used by HIV-1 to kill CD4+ T cells in the...

Amanda K Steele, Eric J Lee, Jennifer A Manuzak, Stephanie M Dillon… in Retrovirology (2014)

Article

Nef-mediated TCR-CD3 and MHC-I down-modulation prevents CD4+ T cell depletion in natural SIV infection

Michael Schindler, Jan Münch, Olaf Kutsch, Hui Li, Mario L Santiago… in Retrovirology (2006)