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Article
Open AccessDifferent antiviral effects of IFNα subtypes in a mouse model of HBV infection
Interferon alpha (IFNα) is commonly used for the treatment of chronic hepatitis B (CHB) patients. There are 13 different IFNα subtypes in humans, but only the subtype IFNα2 is used for clinical treatment. The ...
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Article
Open AccessActivated regulatory T cells suppress effector NK cell responses by an IL-2-mediated mechanism during an acute retroviral infection
It is well established that effector T cell responses are crucial for the control of most virus infections, but they are often tightly controlled by regulatory T cells (Treg) to minimize immunopathology. NK ce...
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Article
Open AccessFriend retrovirus drives cytotoxic effectors through Toll-like receptor 3
Pathogen recognition drives host defense towards viral infections. Specific groups rather than single members of the protein family of pattern recognition receptors (PRRs) such as membrane spanning Toll-like r...
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Article
Open AccessDistinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection
In many virus infections natural killer (NK) cells are critical for the rapid containment of virus replication. Polymorphisms in NK cell receptors as well as viral escape from NK cell responses are associated ...
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Article
Open AccessNK cells improve control of friend virus infection in mice persistently infected with murine cytomegalovirus
Co-infection of HIV patients with cytomegalovirus (CMV) is associated with enhanced AIDS progression and CMV end-organ diseases. On the other hand, persistent CMV infection has recently been shown to decrease ...
