Advances in TNF Family Research
Proceedings of the 12th International TNF Conference, 2009
Page
%P
-
Article
25 years of biologic DMARDs in rheumatology
2023 marks 25 years since the approval of the first biologic drug in rheumatology. In this Viewpoint, five rheumatology researchers discuss how biologic therapy has transformed clinical practice, reflecting on...
-
Article
Open AccessC-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis
Macrophages are integral to the pathogenesis of atherosclerosis, but the contribution of distinct macrophage subsets to disease remains poorly defined. Using single cell technologies and conditional ablation v...
-
Article
Von Dashboards zu Dashboarding
-
Article
An inflammatory cytokine signature predicts COVID-19 severity and survival
Several studies have revealed that the hyper-inflammatory response induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major cause of disease severity and death. However, predictive bi...
-
Article
Open AccessAuthor Correction: Cellular census of human fibrosis defines functionally distinct stromal cell types and states
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Open AccessCellular census of human fibrosis defines functionally distinct stromal cell types and states
Fibrotic disorders are some of the most devastating and poorly treated conditions in developed nations, yet effective therapeutics are not identified for many of them. A major barrier for the identification of...
-
Article
Open AccessNovel biomarkers of a peripheral blood interferon signature associated with drug-naïve early arthritis patients distinguish persistent from self-limiting disease course
We profiled gene expression signatures to distinguish rheumatoid arthritis (RA) from non-inflammatory arthralgia (NIA), self-limiting arthritis (SLA), and undifferentiated arthritis (UA) as compared to healthy...
-
Article
Macrophage heterogeneity in the context of rheumatoid arthritis
Macrophages are of critical importance in rheumatoid arthritis (RA), as they generate cytokines that enhance inflammation and contribute to destruction of cart...
-
Article
Preclinical target validation using patient-derived cells
The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies.
-
Article
Open AccessStimulation of the α7 Nicotinic Acetylcholine Receptor Protects against Neuroinflammation after Tibia Fracture and Endotoxemia in Mice
Surgery and critical illness often associate with cognitive decline. Surgical trauma or infection can lead independently to learning and memory impairments via similar, but not identical, cellular signaling of...
-
Chapter
Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure
Anti-tumor necrosis factor (TNF) therapy was the first successful anti-cytokine therapy, and its discovery was based on detailed examination of human disease tissue in rheumatoid arthritis and on exploring the...
-
Article
Open AccessDifferential effects of Th1 versus Th2 cytokines in combination with hypoxia on HIFs and angiogenesis in RA
Hypoxia and T-helper cell 1 (Th1) cytokine-driven inflammation are key features of rheumatoid arthritis (RA) and contribute to disease pathogenesis by promoting angiogenesis. The objective of our study was to ...
-
Article
Open AccessGene expression profiling and functional analysis of angiogenic markers in murine collagen-induced arthritis
Dysregulated angiogenesis is implicated in the pathogenesis of rheumatoid arthritis (RA). To provide a more profound understanding of arthritis-associated angiogenesis, we evaluated the expression of angiogene...
-
Chapter
Host Pattern Recognition Receptors (Toll-Like Receptors, RIG-I-Like Receptors, NOD-Like Receptors) and Atherosclerosis
Inflammation is an ancient and evolutionarily conserved process, which aims to clear the offending stimulus, and leads to resolution and healing. If excessive, inflammation is at the core of the pathogenesis o...
-
Article
Open AccessHuman epidermal growth factor receptor bispecific ligand trap RB200: abrogation of collagen-induced arthritis in combination with tumour necrosis factor blockade
Rheumatoid arthritis (RA) is a chronic disease associated with inflammation and destruction of bone and cartilage. Although inhibition of TNFα is widely used to treat RA, a significant number of patients do no...
-
Article
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Macrophages are functionally highly plastic, but the transcriptional control of this process is only partially understood. Udalova and colleagues demonstrate that the transcription factor IRF5 controls the pla...
-
Book and Conference Proceedings
-
Article
Open AccessApremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis
Type 4 phosphodiesterases (PDE4) play an important role in immune cells through the hydrolysis of the second messenger, cAMP. Inhibition of PDE4 has previously been shown to suppress immune and inflammatory re...
-
Article
Open AccessThe impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
The impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation be...
-
Article
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
Tumor necrosis factor (TNF) is expressed at high levels in synovial tissue from patients with RA. Through preclinical studies, animal model studies and human trials, this cytokine was the first to be fully val...
