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  1. Article

    Open Access

    Macrophage responses to lipopolysaccharide are modulated by a feedback loop involving prostaglandin E2, dual specificity phosphatase 1 and tristetraprolin

    In many different cell types, pro-inflammatory agonists induce the expression of cyclooxygenase 2 (COX-2), an enzyme that catalyzes rate-limiting steps in the conversion of arachidonic acid to a variety of lip...

    Tina Tang, Thomas E. Scambler, Tim Smallie, Helen E. Cunliffe… in Scientific Reports (2017)

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  2. No Access

    Article

    IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

    Macrophages are functionally highly plastic, but the transcriptional control of this process is only partially understood. Udalova and colleagues demonstrate that the transcription factor IRF5 controls the pla...

    Thomas Krausgruber, Katrina Blazek, Tim Smallie, Saba Alzabin… in Nature Immunology (2011)