9 Result(s)
within
Manuela Teresa Raimondi
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Article
Open AccessBone Marrow Mesenchymal Stem Cells Expanded Inside the Nichoid Micro-Scaffold: a Focus on Anti-Inflammatory Response
Mesenchymal stem cells (MSCs) represent a promising source for stem cell therapies in numerous diseases, including pediatric respiratory system diseases. Characterized by low immunogenicity, high anti-inflamma...
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Article
Open AccessUnravelling the mechanotransduction pathways in Alzheimer’s disease
Alzheimer’s disease (AD) represents one of the most common and debilitating neurodegenerative disorders. By the end of 2040, AD patients might reach 11.2 million in the USA, around 70% higher than 2022, with s...
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Protocol
A Human Neurovascular Unit On-a-Chip
Protection of the central nervous system (CNS) and cerebral homeostasis depend upon the blood–brain barrier (BBB) functions and permeability. BBB restrictive permeability hinders drug delivery for the treatmen...
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Article
Open AccessThe nuclear import of the transcription factor MyoD is reduced in mesenchymal stem cells grown in a 3D micro-engineered niche
Smart biomaterials are increasingly being used to control stem cell fate in vitro by the recapitulation of the native niche microenvironment. By integrating experimental measurements with numerical models, we ...
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Article
Open AccessMechanical regulation of nucleocytoplasmic translocation in mesenchymal stem cells: characterization and methods for investigation
Mesenchymal stem cells (MSCs) have immune-modulatory and tissue-regenerative properties that make them a suitable and promising tool for cell-based therapy application. Since the bio-chemo-mechanical environme...
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Article
Open AccessInfluence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture
Hydraulic sealing is a crucial condition for the maintenance of sterility during long term operation of microfluidic bioreactors. We developed a miniaturized optically accessible bioreactor (MOAB) allowing per...
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Article
The effect of polyurethane scaffold surface treatments on the adhesion of chondrocytes subjected to interstitial perfusion culture
The purpose of this study was to measure chondrocytes detachment from cellularized constructs cultured in a perfusion bioreactor, and to evaluate the effect of different scaffold coatings on cell adhesion unde...
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Article
Characterization of articular chondrocytes isolated from 211 osteoarthritic patients
We analyzed specific features of chondrocytes as cellular yield, cell doubling rates and the dependence between these parameters and patient-related data in a set of 211 osteoarthritic (OA) patients undergoing...
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Chapter
Multiphysics Computational Modeling in Cartilage Tissue Engineering
A common technique for in vitro cartilage regeneration is to seed a porous matrix with cartilage cells and to culture the construct in static conditions or under medium perfusion in a bioreactor. An essential ...
