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Article
Open AccessHydrogel-based delivery of Tat-fused protein Hsp70 protects dopaminergic cells in vitro and in a mouse model of Parkinson’s disease
Neurodegenerative disorders such as Parkinson’s disease (PD) have no effective therapies. However, many promising drugs are precluded from clinical trials because of their poor brain availability. The chaperon...
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Article
Open AccessInfluence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture
Hydraulic sealing is a crucial condition for the maintenance of sterility during long term operation of microfluidic bioreactors. We developed a miniaturized optically accessible bioreactor (MOAB) allowing per...
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Article
Cross-linked poly(acrylic acids) microgels and agarose as semi-interpenetrating networks for resveratrol release
Carbomers, cross-linked poly(acrylic acid) microgels, have been widely used in pharmaceutical formulations as swollen hydrogels. Agarose, whose thermoreversibility may be exploited for drug loading, forms a ge...
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Article
Efficacy of Zosteric Acid Sodium Salt on the Yeast Biofilm Model Candida albicans
Candida albicans is the most notorious and the most widely studied yeast biofilm former. Design of experiments (DoE) showed that 10 mg/L zosteric acid sodium salt reduced C. albicans adhe...