14 Result(s)
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Cell Biology
Makoto Suzuki
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Article
Open AccessOnionin A inhibits small-cell lung cancer proliferation through suppressing STAT3 activation induced by macrophages-derived IL-6 and cell–cell interaction with tumor-associated macrophage
Tumor-associated macrophage (TAM)-derived IL-6 is involved in small-cell lung cancer (SCLC) progression and chemoresistance via the activation of signal transducer and activator of transcription 3 (STAT3) in t...
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Article
Open AccessA novel Menin-MLL1 inhibitor, DS-1594a, prevents the progression of acute leukemia with rearranged MLL1 or mutated NPM1
Mixed lineage leukemia 1-rearranged (MLL1-r) acute leukemia patients respond poorly to currently available treatments and there is a need to develop more effective therapies directly disrupting the Menin‒MLL1 com...
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Article
Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer
The present study investigated the expression and role of ROR2 in small cell lung cancer (SCLC). To examine the expression of ROR2, 27 surgically resected SCLC tissue samples were immunostained for ROR2. Sixte...
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Article
LC–MS/MS-based metabolome analysis detected changes in the metabolic profiles of small and large intestinal adenomatous polyps in Apc Min/+ mice
The adenomatous polyposis coli (APC) gene is a tumor suppressor gene that is inactivated in the initiation of colorectal neoplasia. Apc Min/+ mice, which ...
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Chapter
TRP Channels and Mechanical Signals
Transient receptor potential (TRP) channels are a unique cellular mechanism converting a wide variety of signals, including mechanical stress, to cation flow. The protein was first discovered in studies that e...
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Article
Rice-Arabidopsis FOX line screening with FT-NIR-based fingerprinting for GC-TOF/MS-based metabolite profiling
The full-length cDNA over-expressing (FOX) gene hunting system is useful for genome-wide gain-of-function analysis. The screening of FOX lines requires a high-throughput metabolomic method that can detect a wi...
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Chapter
Mechanosensitive Channel TRPV4
The transient receptor potential vanilloid 4 (TRPV4), a member of the TRP family that has a 6-transmembrane (TM) segment, was first identified as a hypoosmolality-activated Ca2+ permeable channel. The mechanism o...
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Chapter and Conference Paper
Molecular Breeding of Low-Phytic-Acid Grains in Rice by Using the Promoter of 18 kDa Oleosin
In most plant seeds, phosphorus is stored primarily as myo-inositol 1,2,3,4,5,6-hexakisphosphate (InsP6; phytic acid). Monogastric animals are unable to utilize phytic acid phosphorus efficiently because they lac...
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Article
Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study
Centenarians represent a rare phenotype appearing in roughly 10–20 per 100,000 persons in most industrialized countries but as high as 40–50 per 100,000 persons in Okinawa, Japan. Siblings of centenarians in O...
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Article
Caloric restriction and human longevity: what can we learn from the Okinawans?
Caloric (or dietary) restriction (CR) extends lifespan and lowers risk for age associated diseases in a phylogenetically diverse group of species. Whether prolonged CR increases average or maximum lifespan or ...
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Article
Aberrant methylation profile of human malignant mesotheliomas and its relationship to SV40 infection
Malignant mesothelioma (MM) is associated with asbestos exposure and the presence of SV40 viral sequences. Recently, we reported that SV40 infection of human mesothelial cells (HM) causes aberrant methylation ...
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Article
Modulation of actomyosin motor function by 1-hexanol
This study examines the effects of 1-hexanol as a perturbing agent on actomyosin ATPase and its related functions in the concentration range between 0 and 20 mM. In this range the denaturation of myosin subfra...
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Article
Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival
Inactivation of the FANC–BRCA pathway via promoter methylation of the FANCF gene renders cells sensitive to DNA crosslinking agents, and has been identified in ovarian cancer cell lines and sporadic primary tu...
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Article
Glutathione-dependent inactivation of sodium-dependent phosphate transport across rat renal brush-border membrane
Thiol/disulfide is fundamental in protein function; we previously observed an inhibitory effect of thiol oxidants on the Na-dependent phosphate (Pi) uptake into renal brush border membrane vesicles (BBMV). We ...
