28 Result(s)

Article

Salivary metabolomics with alternative decision tree-based machine learning methods for breast cancer discrimination

The aim of this study is to explore new salivary biomarkers to discriminate breast cancer patients from healthy controls.

Takeshi Murata, Takako Yanagisawa… in Breast Cancer Research and Treatment (2019)

Article

S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is the 5th most common cause of cancer death in the UK and the 4th in the US. The vast majority of deaths following pancreatic cancer are due to metastatic spread, hence...

Sayka Barry, Claude Chelala, Kate Lines… in Clinical & Experimental Metastasis (2013)

Article

Surgery versus radiochemotherapy for resectable locally invasive pancreatic cancer: Final results of a randomized multi-institutional trial

Although the outcome of surgery for locally advanced pancreatic cancer remains poor, it is improving, with 5-year survival up to about 10% in Japan. The preliminary results of our multi-institutional randomize...

Ryuichiro Doi, Masayuki Imamura, Ryo Hosotani, Toshihide Imaizumi… in Surgery Today (2008)

Article

The PMAIP1 Gene on Chromosome 18 is a Candidate Tumor Suppressor Gene in Human Pancreatic Cancer

Frequent loss of heterozygosity on the long arm of chromosome 18 is observed in pancreatic cancer. Previous studies suggested the existence of one or more tumor-suppressor genes other than SMAD4 on chromosome 18....

Masaharu Ishida, Makoto Sunamura, Toru Furukawa… in Digestive Diseases and Sciences (2008)

Article

Intraductal papillary-mucinous adenocarcinoma in the remnant pancreas after pancreatoduodenectomy for cancer of Vater's papilla associated with intraductal papillary-mucinous adenoma

A 72-year-old woman, who had undergone pylorus-preserving pancreatoduodenectomy 3 years before for cancer of Vater's papilla associated with a branch-type intraductal papillary-mucinous adenoma (IPMA), develop...

Masaharu Ishida, Shinichi Egawa… in Journal of Hepato-Biliary-Pancreatic Surge… (2007)

Article

Classification of types of intraductal papillary-mucinous neoplasm of the pancreas: a consensus study

Now that more than two decades have passed since the first reports of intraductal papillary-mucinous neoplasms (IPMNs), it has become clear that IPMN consists of a spectrum of neoplasms with both morphological...

Toru Furukawa, Günter Klöppel, N. Volkan Adsay, Jorge Albores-Saavedra… in Virchows Archiv (2005)

Article

Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer

Angiogenesis is necessary for the continued growth of solid tumors, invasion and metastasis. Several studies clearly showed that heme oxygenase-1 (HO-1) plays an important role in angiogenesis. In this study, ...

Makoto Sunamura, Dan G. Duda, Maivel H. Ghattas, Lucian Lozonschi… in Angiogenesis (2003)

Article

Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells

SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-β)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4...

Dan G Duda, Makoto Sunamura, Liviu P Lefter, Toru Furukawa, Tadaaki Yokoyama… in Oncogene (2003)

Article

Gene therapy for pancreatic cancer targeting the genomic alterations of tumor suppressor genes using replication-selective oncolytic adenovirus

In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we examined the genetic alternations of pancreatic cancer. Based on these results, we are develo** a new gene th...

Makoto Sunamura, Masaru Oonuma, Fuyuhiko Motoi, Hisashi Abe, Yukoh Saitoh… in Human Cell (2002)

Article

Gene therapy for pancreatic cancer based on genetic characterization of the disease

In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we analyzed the association of loss of heterozygosity (LOH) with the clinicopathological features of the disease....

Makoto Sunamura, Toshimasa Yatsuoka… in Journal of Hepato-Biliary-Pancreatic Surge… (2002)

Chapter

Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells

Makoto Sunamura in Cancer Gene Therapy (2002)

Article

Early Microcirculatory Derangement in Mild and Severe Pancreatitis Models in Mice

An in vivo microscopic technique was used to clarify the increase in microvascular permeability and enhanced leukocyte–endothelium interaction of pancreatic microcirculation in experimental pancreatitis of di...

Han-Ming Chen, Makoto Sunamura, Kazuhiko Shibuya, Jun-ichiro Yamauchi… in Surgery Today (2001)

Article

Cytokine modulation in acute pancreatitis

The clinical manifestations of acute pancreatitis (AP) vary significantly from mild to lethal in form, the severity of the disease being largely determined by the actions of various kinds of inflammatory medi...

Jun-ichiro Yamauchi, Kazuhiko Shibuya… in Journal of Hepato-Biliary-Pancreatic Surge… (2001)

Chapter and Conference Paper

Cytotoxic Effect of Bone Marrow-Derived Dendritic Cells

Some reports suggest that cancer patients have a better prognosis when dendritic cells (DCs) infiltrate their tumors. Although the role of these DCs is not fully understood, we focused on a potential effector ...

Hiromune Shimamura, Fuyuhiko Motoi… in Trends in Gastroenterology and Hepatology (2001)

Chapter and Conference Paper

Controlling Tumor Microenvironment by the Antiangiogenesis Strategy

Angiogenesis occurs when the balance between negative and positive regulators inclines toward the latter, allowing the tumor and metastases to develop. Studies have found that genetic alterations may correlate...

Makoto Sunamura, Dan G. Duda, Lucian Lozonschi… in Trends in Gastroenterology and Hepatology (2001)

Article

Preventing effect of anti-ICAM-1 and anti-LFA-1 monoclonal antibodies on murine islet allograft rejection

Immunosuppressive potentials of the blockade of intercellular adhesion molecule-1 (ICAM)-1/leukocyte function-associated antigen 1 (LFA-1) were examined in a murine islet allotransplantation model by using blo...

Kosuke Arai, Makoto Sunamura, Yasushi Wada… in International Journal of Pancreatology (1999)