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  1. No Access

    Article

    Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells

    SMAD4 is a critical cofactor in signal transduction pathways activated in response to transforming growth factor-beta (TGF-β)-related ligands, regulating cell growth and differentiation. The roles played by SMAD4...

    Dan G Duda, Makoto Sunamura, Liviu P Lefter, Toru Furukawa, Tadaaki Yokoyama… in Oncogene (2003)

  2. No Access

    Article

    Gene therapy for pancreatic cancer based on genetic characterization of the disease

    In order to develop an effective therapeutic intervention for patients with pancreatic cancer, we analyzed the association of loss of heterozygosity (LOH) with the clinicopathological features of the disease....

    Makoto Sunamura, Toshimasa Yatsuoka… in Journal of Hepato-Biliary-Pancreatic Surge… (2002)

  3. No Access

    Article

    Genomic analysis of the thymine-DNA glycosylase (TDG) gene on 12q22–q24.1 in human pancreatic ductal adenocarcinoma

    Background. Recently, a human G/T-specific TDG gene was identified. This protein acts in a system correcting G/T mispairs to G/C pairs. TDG was mapped to chromosome bands 12q22–q24.1, one of the ...

    Toshimasa Yatsuoka, Toru Furukawa, Tadayoshi Abe… in International Journal of Pancreatology (1999)

  4. No Access

    Article

    PTEN1 is frequently mutated in primary endometrial carcinomas

    Dehe Kong, Akihiko Suzuki, Tong-Tong Zou, Akira Sakurada… in Nature Genetics (1997)