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Article
Open AccessOpinion, knowledge, and clinical experience with functional neurological disorders among Italian neurologists: results from an online survey
Functional neurological disorders (FND) are disabling medical conditions commonly seen in neurological practice. Neurologists play an essential role in managing FND, from establishing a diagnosis to coordinati...
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Article
Open AccessPublisher Correction: A disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessA disulfide constrains the ToxR periplasmic domain structure, altering its interactions with ToxS and bile-salts
ToxR is a transmembrane transcription factor that, together with its integral membrane periplasmic binding partner ToxS, is conserved across the Vibrionaceae family. In some pathogenic Vibrios, including V. parah...
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Article
Open AccessThe IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface
NEMO is an essential component in the activation of the canonical NF-κB pathway and exerts its function by recruiting the IκB kinases (IKK) to the IKK complex. Inhibition of the NEMO/IKKs interaction is an att...
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Article
Backbone and side chain resonance assignments for a structured domain within Atg32
Autophagy is a catabolic cellular process that targets cytosolic material, including mitochondria, to the vacuole or lysosomes for degradation. The selective degradation of mitochondria by autophagy is termed ...
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Article
Open AccessA new class of inhibitors of the AraC family virulence regulator Vibrio cholerae ToxT
Vibrio cholerae is responsible for the diarrheal disease cholera that infects millions of people worldwide. While vaccines protecting against cholera exist, and oral rehydration therapy is an effective treatment ...
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Article
Open AccessA novel caspase 8 selective small molecule potentiates TRAIL-induced cell death
Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors (DR4 and DR5) are currently being created for clinical cancer therapy, due to their selective killing of cancer cells and high safety ...
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Molecular characterization of the interaction between parathyroid hormone and its receptor
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Chapter
Identification and exploitation of structural foci that influence conformational mobility in somatostatin agonists and antagonists
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Secondary and tertiary fold of the human parathyroid hormone1–34 in different environments as a pathway to bioactive conformation
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Lactam cyclization [i to (i+4)] for nucleation/stabilization of α-helices?
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RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity
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Chapter
CtrΔe13, a Calcitonin Receptor Isoform Lacking 14 Amino Acids in Transmembrane Helix 7: Structure and Topology
The peptide hormone calcitonin (CT) acts through its G-protein coupled receptor to reduce serum calcium levels by inhibiting bone resorption and promoting renal calcium excretion. In addition, CT modulates the...
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Probing the Importance of the N-Terminal Helix of Parathyroid Hormone: Introduction of Cyclohexylalanine to Tether to the Membrane
We have previously described the structural features of parathyroid hormone (PTH) as determined by high-resolution NMR under a number of different conditions, including the membrane mimetic environment of dode...
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Characterizing the Interactions Between Cholecystokinin and the G-Protein Coupled Receptors CCK1 and CCK2: An NMR-Based Study
Cholecystokinin (CCK) is a peptide hormone and neurotransmitter involved in a number of physiological processes of the gall bladder and pancreas, in the gastrointestinal tract, and anxiety, memory, and analges...
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Article
Conformational investigation of a novel dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
1,2,5-Trisubstituted 1,4-diazepine-3-one: A novel dipeptidomimetic molecular scaffold
The continuing effort to transform bioactive peptides into non-peptide peptidomimetics of therapeutic potential requires a diversity of tools such as molecular scaffolds, pseudopeptide modifications, and confo...
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Article
Conformational investigation of a novel, dipeptide based molecular scaffold
The conformational features of a novel, dipeptide-based molecular scaffold are described. Four model systems of a trisubstituted 1,4-diazepine-3-one system, varying in the chirality and amino acid within the r...
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Article
Serum, insulin and phorbol esters stimulate rRNA and tRNA gene expression in both dividing and nondividing Drosophila cells
The expression of genes that code for the large ribosomal RNAs (rRNAs) and tRNAs can be regulated by calcium, serum, insulin and a tumor-promoting phorbol ester, TPA. These effectors can rapidly alter rRNA and...
