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  1. No Access

    Article

    Induction of leptin resistance through direct interaction of C-reactive protein with leptin

    The mechanisms underlying leptin resistance are still being defined. We report here the presence in human blood of several serum leptin-interacting proteins (SLIPs), isolated by leptin-affinity chromatography ...

    Ke Chen, Fanghong Li, Ji Li, Hongbo Cai, Steven Strom… in Nature Medicine (2006)

  2. No Access

    Article

    Safety and tolerability of subcutaneous PTHrP(1–36) in healthy human volunteers: a dose escalation study

    Parathyroid hormone-related protein (PTHrP) is an anabolic skeletal agent in mice, rats and humans. In previous studies, we have demonstrated that PTHrP can be administered to osteoporotic postmenopausal women...

    Mara J. Horwitz, Mary Beth Tedesco, Susan M. Sereika… in Osteoporosis International (2006)

  3. No Access

    Chapter

    Conformational studies of a D-Trp12-substituted PTHrP-derived antagonist containing lactam-bridged side-chains

    Stefano Maretto, Elisabetta Schievano… in Peptides Frontiers of Peptide Science (2002)

  4. No Access

    Chapter

    Parathyroid hormone-related protein derived mono- and bicyclic agonists and antagonists: A conformational comparison

    Stefano Maretto, Elisabetta Schievano… in Peptides Frontiers of Peptide Science (2002)

  5. No Access

    Chapter

    RS-66271, a clinical candidate derived from parathyroid hormone related protein: The role of enhanced amphiphilic helicity

    Maria Pellegrini, Alessandro Bisello… in Peptides Frontiers of Peptide Science (2002)

  6. No Access

    Chapter

    Structure-Function Relationship Studies on Parathyroid Hormone (PTH) 1–34 Analogs Containing β-Amino Acid Residues in Positions 11, 12, and 13

    Parathyroid hormone (PTH) is an 84 amino acid residue peptide, which plays a key physiological role in the regulation of calcium levels in serum. Virtually, all bone-relevant activities of PTH are encoded in t...

    Evaristo Peggion, Stefano Mammi, Elisabetta Schievano… in Peptides: The Wave of the Future (2001)

  7. No Access

    Chapter

    Ligand-Receptor Interactions Regulating Cell Trafficking and Signaling of the Human PTH1Rc: An in Silica Examination

    Desensitization of G-protein coupled receptors is a fundamental mechanism regulating the cellular response to agonists. It was recently demonstrated that stimulation of the human parathyroid hormone (PTH)/para...

    Luca Monticelli, Stefano Mammi, Evaristo Peggion… in Peptides: The Wave of the Future (2001)

  8. No Access

    Chapter

    Local Conformation Around Position 12 of the (1–34) Fragment of Parathyroid Hormone Probed by Substitution with Aib Residues

    Parathyroid hormone (PTH) controls the homeostasis of calcium ions in the blood. Its N-terminal 1–34 fragment is sufficient to reproduce all the physiological functions elicited by the intact hormone. The biol...

    Evaristo Peggion, Stefano Mammi, Elisabetta Schievano… in Peptides: The Wave of the Future (2001)