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Article
Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases
We investigated whether polymorphisms in the CYP2D6 and CYP2C19 genes influence the metabolic ratios and enantiomeric S/R ratios of venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylv...
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Article
Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers
Objective: This study was performed to assess whether coadminstration with grapefruit juice significantly affects the pharmacokinetics of amlodipine, a dihydropyridine class calcium anta...
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Article
Fast chromatographic separation of (−)-menthyl chloroformate derivatives of some chiral drugs, with special reference to amlodipine, on porous graphitic carbon
Enantiomeric separation of (−)-menthyl chloroformate derivatives of some chiral cardioactive drugs, on porous graphitic carbon (PGC), Hypercarb-S, is described. Capacity and separation factors of derivatives o...
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Article
Chiral separation of aminoalcohols by ion-pair chromatography
A new chiral counter ion, N-benzoxycarbonyl-glycyl-L-proline (ZGP), added to the organic mobile phase (dichloromethane) has been used for separation of enantiomers of aminoalcohols with LiChrosorb DIOL as the ...