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  1. Article

    Open Access

    Intox - A Prospective Measurement of Blood Concentrations of Routine Drugs in Patients Treated in the Intensive Care Unit

    U Lennborn, E Nielsen, H Sandler, M Bertilsson… in Intensive Care Medicine Experimental (2015)

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    Article

    ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram

    P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood–brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby...

    L. Karlsson, H. Green, A. L. Zackrisson… in International Journal of Legal Medicine (2013)

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    Article

    Dose–hair concentration relationship and pigmentation effects in patients on low-dose clozapine

    Several hair components have been suggested as possible molecular sites for drug binding and interaction. Of these, keratin and melanin have been investigated in some detail in order to assess the mechanisms b...

    R. Kronstrand, M. Roman, M. Hedman, J. Ahlner… in Forensic Science, Medicine, and Pathology (2007)

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    Article

    Fatal intoxication cases: cytochrome P 450 2D6 and 2C19 genotype distributions

    Many commonly used pharmaceuticals, such as antidepressants and neuroleptics as well as some illegal drugs, are metabolised by the cytochrome P 450 enzyme debrisoquine 4-hydroxylase (CYP2D6). Of Caucasians, 7–10...

    A. L. Zackrisson, P. Holmgren, A. B. Gladh… in European Journal of Clinical Pharmacology (2004)

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    Article

    Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers

    Objective: This study was performed to assess whether coadminstration with grapefruit juice significantly affects the pharmacokinetics of amlodipine, a dihydropyridine class calcium anta...

    M. Josefsson, A.-L. Zackrisson, J. Ahlner in European Journal of Clinical Pharmacology (1996)

  6. No Access

    Article

    Decreased plasma levels of cyclic GMP in patients with chest pain and angiographically normal coronary arteries

    Plasma levels of cyclic nucleotides were determined by radioimmunoassy in patients with (1) angina-like chest pain and normal coronary arteries (suspected spasm angina), (2) exercise-induced angina, and (3) he...

    J. Ahlner, R. G. G. Andersson, K. L. Axelsson, B. Bergdahl… in Klinische Wochenschrift (1988)

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    Article

    Nitrate Tolerance from a Biochemical Point of View

    Tolerance to nitrate vasodilators appears to be a general phenomenon that encompasses all known drugs belonging to this group, with the possible exception of molsidomine, for which tolerance has not yet been u...

    Dr Krister Axelsson, J. Ahlner in Drugs (1987)