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  1. No Access

    Article

    Influence of CYP2D6 and CYP2C19 genotypes on venlafaxine metabolic ratios and stereoselective metabolism in forensic autopsy cases

    We investigated whether polymorphisms in the CYP2D6 and CYP2C19 genes influence the metabolic ratios and enantiomeric S/R ratios of venlafaxine (VEN) and its metabolites O-desmethylvenlafaxine (ODV), N-desmethylv...

    L Karlsson, A-L Zackrisson, M Josefsson, B Carlsson… in The Pharmacogenomics Journal (2015)

  2. No Access

    Article

    ABCB1 gene polymorphisms are associated with fatal intoxications involving venlafaxine but not citalopram

    P-glycoprotein (P-gp), encoded by the ABCB1/MDR1 gene, is a drug transporter at the blood–brain barrier. Several polymorphisms in the ABCB1 gene are known to affect the activity and/or expression of P-gp, thereby...

    L. Karlsson, H. Green, A. L. Zackrisson… in International Journal of Legal Medicine (2013)

  3. No Access

    Article

    Fatal intoxication cases: cytochrome P 450 2D6 and 2C19 genotype distributions

    Many commonly used pharmaceuticals, such as antidepressants and neuroleptics as well as some illegal drugs, are metabolised by the cytochrome P 450 enzyme debrisoquine 4-hydroxylase (CYP2D6). Of Caucasians, 7–10...

    A. L. Zackrisson, P. Holmgren, A. B. Gladh… in European Journal of Clinical Pharmacology (2004)

  4. No Access

    Article

    Effect of grapefruit juice on the pharmacokinetics of amlodipine in healthy volunteers

    Objective: This study was performed to assess whether coadminstration with grapefruit juice significantly affects the pharmacokinetics of amlodipine, a dihydropyridine class calcium anta...

    M. Josefsson, A.-L. Zackrisson, J. Ahlner in European Journal of Clinical Pharmacology (1996)