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  1. No Access

    Article

    Derivation of Induced Pluripotent Stem Cells Line (RCPCMi009-A-1) with Knockout of the UBE2A Gene Using CRISPR/Cas9 Genome Editing

    The deletions and mutations in the UBE2A gene cause X-linked mental retardation syndrome of the Nascimento type first described in 2006 (Nascimento et al., 2006). At the moment, approximately two dozen missense a...

    E. A. Khomyakova, A. V. Fedorenko… in Russian Journal of Developmental Biology (2023)

  2. No Access

    Article

    Methylation of the Human AR Locus Does Not Correlate with the Presence of Inactivated X Chromosome in Induced Pluripotent Stem Cells

    The process of dosage compensation of genes occurs in the female mammalian cells during early embryonic development: one of the two X chromosomes becomes transcriptionally inactive and is subsequently inherite...

    A. V. Panova, A. N. Bogomazova, M. A. Lagarkova… in Russian Journal of Genetics (2020)

  3. No Access

    Article

    Molecular Mechanisms of Spinocerebellar Ataxia Type 1

    Polyglutamine (polyQ) disorders are severe forms of inherited neurodegenerative pathologies caused by the expansion of CAG repeats in specific genes accompanied by abnormal elongation of the polyglutamic resid...

    E. A. Volovikov, A. V. Davidenko, M. A. Lagarkova in Russian Journal of Genetics (2020)

  4. No Access

    Article

    The Role of Mutant RNA in the Pathogenesis of Huntington’s Disease and Other Polyglutamine Diseases

    Polyglutamine diseases are rare, inherited neurodegenerative pathologies that arise as a result of expansion of trinucleotide CAG repeats in the coding segment of certain genes. This expansion leads to the app...

    A. N. Bogomazova, A. V. Eremeev, G. E. Pozmogova, M. A. Lagarkova in Molecular Biology (2019)

  5. No Access

    Article

    At Home among Strangers: Is It Possible to Create Hypoimmunogenic Pluripotent Stem Cell Lines?

    Human pluripotent stem cells, which include embryonic stem cells and induced pluripotent cells (iPSCs), are capable of unlimited division and differentiation into all cells of the body. These cells are conside...

    M. E. Bogomiakova, A. V. Eremeev, M. A. Lagarkova in Molecular Biology (2019)

  6. No Access

    Article

    Such Various Stem Cells

    Perhaps there is no more intriguing topic in modern biology than stem cells. The growing interest in stem cells is dictated by the ability of stem cells to both self-renew and differentiate, at least into seve...

    M. A. Lagarkova in Biochemistry (Moscow) (2019)

  7. No Access

    Article

    Development of Hematopoietic Stem Cells in the Early Mammalian Embryo

    Hematopoietic stem cells (HSCs) were the first stem cells discovered in humans. A. A. Maximov proposed an idea of blood stem cells that was confirmed later by McCulloch and Till experimentally. HSCs were the f...

    S. A. Rybtsov, M. A. Lagarkova in Biochemistry (Moscow) (2019)

  8. No Access

    Article

    “Necessity Is the Mother of Invention” or Inexpensive, Reliable, and Reproducible Protocol for Generating Organoids

    Organoids are three-dimensional (3D) cell cultures that replicate some of the key features of morphology, spatial architecture, and functions of a particular organ. Organoids can be generated from both adult a...

    A. V. Eremeev, E. A. Volovikov, L. D. Shuvalova, A. V. Davidenko… in Biochemistry (Moscow) (2019)

  9. No Access

    Article

    The Diverse Roles of Spliceosomal Proteins in the Regulation of Cell Processes

    The spliceosome is necessary for the removal of intron sequences in transcribed pre-mRNA in eukaryotic cells. More than 200 proteins are involved in the process of pre-mRNA splicing; they coordinate the altern...

    K. S. Anufrieva, V. O. Shender, G. P. Arapidi… in Russian Journal of Bioorganic Chemistry (2019)

  10. No Access

    Article

    Pluripotent Stem Cells for Modelling and Cell Therapy of Parkinson’s Disease

    Studying pathogenesis of neurodegenerative diseases, including Parkinson’s disease (PD), requires adequate disease models. The available patient’s material is limited to biological fluids and post mortem brain sa...

    O. S. Lebedeva, M. A. Lagarkova in Biochemistry (Moscow) (2018)

  11. No Access

    Article

    Genetic cell reprogramming: A new technology for basic research and applied usage

    Gene function disclosure and the development of modern technologies of genetic manipulations offered the possibility of genetic reprogramming application to alter cell specialization. With the involvement of a...

    A. N. Bogomazova, E. M. Vassina, S. L. Kiselev… in Russian Journal of Genetics (2015)

  12. Article

    Open Access

    No DNA damage response and negligible genome-wide transcriptional changes in human embryonic stem cells exposed to terahertz radiation

    Terahertz (THz) radiation was proposed recently for use in various applications, including medical imaging and security scanners. However, there are concerns regarding the possible biological effects of non-io...

    A. N. Bogomazova, E. M. Vassina, T. N. Goryachkovskaya, V. M. Popik… in Scientific Reports (2015)

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  13. No Access

    Article

    Molecular barriers to processes of genetic reprogramming and cell transformation

    Genetic reprogramming by ectopic expression of transcription factor genes induces the pluripotent state in somatic cells. This technology provides an opportunity to establish pluripotent stem cells for each pe...

    I. V. Chestkov, E. A. Khomyakova, E. A. Vasilieva, M. A. Lagarkova… in Biochemistry (Moscow) (2014)

  14. No Access

    Article

    Gap junctional intercellular communication in human embryonic stem cells during spontaneous differentiation

    Yu. Yu. Sharovskaya, M. A. Lagarkova, S. L. Kiselev… in Doklady Biological Sciences (2009)

  15. No Access

    Article

    Derivation of a novel human embryonic stem cell line under serum-free and feeder-free conditions

    A. V. Eremeev, A. V. Svetlakov, A. M. Polstianoy… in Doklady Biological Sciences (2009)

  16. No Access

    Article

    Protein kinases predominately expressed in human ES cell lines during differentiation

    Capacity of human embryonic stem cells (ESC) for unlimited proliferation and differentiation make them an attractive object in fundamental science and medicine. Little is known about the mechanisms that direct...

    E. S. Philonenko, P. Yu. Volchkov, I. A. Mufazalov… in Cell and Tissue Biology (2007)

  17. No Access

    Article

    Stem Cells: Current Trends of Investigations

    M. V. Prizhkova, M. A. Lagarkova in Russian Journal of Developmental Biology (2004)

  18. No Access

    Article

    Serological Analysis of the Repertoire of Human Cancer Antigens and Autoantigens

    The spectrum of human antigens allows a monitoring of various pathological processes such as autoimmune disorders and tumorigenesis. Serological analysis of cDNA expression libraries (SEREX) is now used to sea...

    E. P. Koroleva, M. A. Lagarkova, S. V. Khlgatian, Yu. V. Shebzukhov… in Molecular Biology (2004)

  19. No Access

    Article

    Analysis of Chromatin Structural Transitions by Means of Intercalator Dyes

    W. A. Krajewski, M. A. Lagarkova, N. P. Sharova… in Doklady Biochemistry and Biophysics (2001)

  20. No Access

    Article

    Effect of Histone Terminal Domains on Chromatin Structural Transitions

    V. A. Krajewski, M. A. Lagarkova, N. P. Sharova… in Doklady Biochemistry and Biophysics (2001)