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Article
Use of scintillometric quantitation of unscheduled DNA synthesis in isolated rat hepatocytes for the screening of genotoxic agents
The induction of unscheduled DNA synthesis has been considered as a suitable endpoint for the screening of genotoxic agents. Experimentally, unscheduled DNA synthesis is most frequently measured by autoradiogr...
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Article
Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations
A simple yet effective method (iso-density percoll centrifugation) has been developed for consistently preparing isolated rat liver parenchymal cells with over 98% initial viability. The method has been applie...
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Article
Effects of 3,3′,4,4′-tetrachloroazoxybenzene on selected immune parameters of the mouse
The effects of 3,3′,4,4′-tetrachloroazoxy-benzene (TCAOB) on the immune system of mice was examined and compared with cyclophosphamide (CY). This chemical can be produced as a result of microbial degradation o...
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Article
Reproductive, immunologie, and cytogenetic effects of dietary 3,3′,4,4′-tetrachloroazoxybenzene exposure to mice
The effects of chronic dietary exposure to 3,3′,4,4′-tetrachloroazoxybenzene (TCAOB) on the reproductive efficiency of female Swiss-Webster mice were measured. The immunocompetence of their offspring was assay...
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Article
Embryotoxicity of 3,3′,4,4′-tetrachloroazobenzene and 3,3′,4,4′-tetrachioroazoxybenzene in the chick embryo
The toxicity of 3,3′,4,4′-tetrachloroazobenzene (TCAB) and 3,3′,4,4′-tetrachloroazoxybenzene (TCAOB) to chick embryos was examined. TCAB or TCAOB was dissolved in corn oil and injected into the air cell of fer...
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Article
Reduction of aflatoxin B1 with zinc borohydride: An efficient preparation of aflatoxicol
A simple and mild reduction of aflatoxin B1, involving treatment of aflatoxin B1 with ethereal zinc borohydride to give 57–65% yield of diastereomeric aflatoxicols, is described.
