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  1. No Access

    Protocol

    Genoty** for Functionally Important Human CYP2D6*4 (B) Mutation Using TaqMan Probes

    The microsomal enzyme cytochrome P450 2D6 (CYP2D6), also known as debrisoquine 4-hydroxylase, is involved in the oxidative metabolism of many widely used drugs, including neuroleptics, tricyclic antidepressant...

    Michael M. Shi, Scott P. Myrand, Michael R. Bleavins… in Molecular Pathology Protocols (2001)

  2. No Access

    Chapter

    Changes in Monkey Plasma Purines Induced by Repeated Doses of CI-1000, a Novel Inhibitor of Purine Nucleoside Phosphorylase

    CI-1000, a 9-deazaguanine analog, is an orally active and reversible inhibitor of purine nucleoside Phosphorylase (PNP). In vitro, CI-1000 inhibits human T-lymphoblast replication and the mixed lymphocyte respons...

    Donald G. Robertson, Ellen R. Urda… in Purine and Pyrimidine Metabolism in Man VI… (1994)

  3. No Access

    Article

    Reproductive, immunologie, and cytogenetic effects of dietary 3,3′,4,4′-tetrachloroazoxybenzene exposure to mice

    The effects of chronic dietary exposure to 3,3′,4,4′-tetrachloroazoxybenzene (TCAOB) on the reproductive efficiency of female Swiss-Webster mice were measured. The immunocompetence of their offspring was assay...

    Michael R. Bleavins, Ronald D. Hinsdill… in Archives of Environmental Contamination an… (1985)

  4. No Access

    Chapter and Conference Paper

    Immunotoxicologic effects of polychlorinated biphenyls on the cell-mediated and humoral immune systems

    Polychlorinated biphenyls (PCBs) have become one of the most widespread and persistent environmental pollutants in the world’s terrestrial and aquatic ecosystems (Risebrough et al. 1968, Johnson and Manske 1976, ...

    Michael R. Bleavins, Richard J. Aulerich in Residue Reviews (1983)

  5. No Access

    Article

    Excessive nail growth in the European ferret induced by Aroclor 1242

    European ferrets fed a diet that contained 20 ppm Aroclor 1242 for several months developed elongated, thickened, and deformed toenails. The excessive nail growth was more conspicuous in the males than in the ...

    Michael R. Bleavins, Richard J. Aulerich… in Archives of Environmental Contamination an… (1982)

  6. No Access

    Article

    Polychlorinated biphenyls (Aroclors® 1016 and 1242): Effect on hepatic microsomal mixed function oxidases in mink and ferrets

    A comparison was made of the induction responses of two PCBs (Aroclors 1016 and 1242) on the hepatic microsomal mixed function oxidase (MFO) system in two genetically similar species, mink and European ferrets...

    Lee R. Shull, Michael R. Bleavins… in Archives of Environmental Contamination an… (1982)

  7. No Access

    Article

    Polychlorinated biphenyls (Aroclors 1016 and 1242): Effects on survival and reproduction in mink and ferrets

    Diets that contained various levels of supplemental Aroclor® 1242 or Aroclor® 1016 were fed to mink and ferrets to investigate the chronic toxicity of these PCBs in two closely related species.

    Michael R. Bleavins, Richard J. Aulerich… in Archives of Environmental Contamination an… (1980)