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Open AccessGenetic risk for schizophrenia is associated with altered visually-induced gamma band activity: evidence from a population sample stratified polygenic risk
Gamma oscillations (30–90 Hz) have been proposed as a signature of cortical visual information processing, particularly the balance between excitation and inhibition, and as a biomarker of neuropsychiatric dis...
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Open AccessErratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Correction to: Molecular Psychiatry (2017) 22: 1502-1508; advance online publication, 12 July 2017; doi: 10.1038/mp.2016.97 In the first paragraph of the Results section and Figure 1, the authors incorrectly r...
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Article
Open AccessErratum: Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
Correction to: Molecular Psychiatry advance online publication, 12 July 2016; doi:10.1038/mp.2016.97 The ninth author’s name was presented incorrectly. It should have been listed as LF Jarskog.
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Article
Open AccessGenome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia
The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however, its use is limited by its potential to induce agranulocytosis. The causes of this, and of its precursor neutropeni...
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Article
Open AccessInvestigating the genetic underpinnings of early-life irritability
Severe irritability is one of the commonest reasons prompting referral to mental health services. It is frequently seen in neurodevelopmental disorders that manifest early in development, especially attention-...
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Article
Open AccessGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipola...
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Open AccessSchizophrenia copy number variants and associative learning
Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variant...
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Article
Open AccessMiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls
Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the ...
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Open AccessErratum: Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Correction to: Molecular Psychiatry 21, 749–757; doi:10.1038/mp.2016.49 The GWAS of neuroticism conducted within the Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute cohort ...
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Open AccessPsychiatric gene discoveries shape evidence on ADHD’s biology
A strong motivation for undertaking psychiatric gene discovery studies is to provide novel insights into unknown biology. Although attention-deficit hyperactivity disorder (ADHD) is highly heritable, and large...
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Erratum: Common alleles contribute to schizophrenia in CNV carriers
Correction to: Molecular Psychiatry (2015); advance online publication 22 September 2015; doi:10.1038/mp.2015.143 The first author in Reference 33 was listed incorrectly in the reference list and in the last p...
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Article
Open AccessCommon alleles contribute to schizophrenia in CNV carriers
The genetic architecture of schizophrenia is complex, involving risk alleles ranging from common alleles of weak effect to rare alleles of large effect, the best exemplar of the latter being large copy number ...
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Article
Open AccessGenome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci
Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive disorder (MDD) and several other psychiatric conditi...
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Article
Open AccessCopy number variation in bipolar disorder
Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample fr...
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Article
A novel Alzheimer disease locus located near the gene encoding tau protein
APOE ɛ4, the most significant genetic risk factor for Alzheimer disease (AD), may mask effects of other loci. We re-analyzed genome-wide association study (GWAS) data from the International Genomics of Alzheimer’...
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Article
Genetic overlap between Alzheimer’s disease and Parkinson’s disease at the MAPT locus
We investigated the genetic overlap between Alzheimer’s disease (AD) and Parkinson’s disease (PD). Using summary statistics (P-values) from large recent genome-wide association studies (GWAS) (total n=89 904 indi...
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Article
Open AccessExpression analysis in a rat psychosis model identifies novel candidate genes validated in a large case–control sample of schizophrenia
Antagonists of the N-methyl-D-aspartate (NMDA)-type glutamate receptor induce psychosis in healthy individuals and exacerbate schizophrenia symptoms in patients. In this study we have produced an animal model ...
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Open AccessAnalysis of exome sequence in 604 trios for recessive genotypes in schizophrenia
Genetic associations involving both rare and common alleles have been reported for schizophrenia but there have been no systematic scans for rare recessive genotypes using fully phased trio data. Here, we use ...
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Article
Evaluating historical candidate genes for schizophrenia
Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the current status of 25 historical candidate genes for sch...
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Schizophrenia genetics: emerging themes for a complex disorder
After two decades of frustration, genetic studies of schizophrenia have entered an era of spectacular success. Advances in genoty** technologies and high throughput sequencing, increasing analytic rigour and...
