![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
Variability in circulating gas emboli after a same scuba diving exposure
A reduction in ambient pressure or decompression from scuba diving can result in ultrasound-detectable venous gas emboli (VGE). These environmental exposures carry a risk of decompression sickness (DCS) which ...
-
Article
Open AccessComparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study
There are challenges for researchers and clinicians to select the most appropriate physical activity tool, and a balance between precision and feasibility is needed. Currently it is unclear which physical acti...
-
Article
Open AccessMiR-137-derived polygenic risk: effects on cognitive performance in patients with schizophrenia and controls
Variants at microRNA-137 (MIR137), one of the most strongly associated schizophrenia risk loci identified to date, have been associated with poorer cognitive performance. As microRNA-137 is known to regulate the ...
-
Article
Open AccessMipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase I clinical trial in patients with refractory, advanced or metastatic solid tumours
Mipsagargin (G-202; (8-O-(12-aminododecanoyl)-8-O-debutanoyl thapsigargin)-Asp-γ-Glu-γ-Glu-γ-GluGluOH)) is a novel thapsigargin-based targeted prodrug that is activated by PSMA-mediated cleavage of an inert maski...
-
Article
Open AccessA phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours
We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selumetinib (MEK 1/2 inhibitor).
-
Article
Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome
Response to immunosuppressive therapy (IST) in younger patients with myelodysplastic syndrome (MDS) has been linked to a T-cell-dominant autoimmune process that impairs hematopoiesis. Analysis of the age-adjus...
-
Chapter
Future Directions
-
Chapter
THEMIS Operations
THEMIS—a five-spacecraft constellation to study magnetospheric events leading to auroral outbursts—launched on February 17, 2007. All aspects of operations are conducted at the Mission Operations Center at the...
-
Article
THEMIS Operations
THEMIS—a five-spacecraft constellation to study magnetospheric events leading to auroral outbursts—launched on February 17, 2007. All aspects of operations are conducted at the Mission Operations Center at the...
-
Article
Liver tumors
The development and clinical introduction of microbubble contrast agents has had a particular impact on the detection and differential diagnosis of liver tumors. The first approach widely employed made use of ...
-
Article
TNF-α blockade in early rheumatoid significantly reduces serum VEGF and ultrasonographic measures of synovitis and joint vascularity by 18 weeks
-
Article
Inflammatory arthritis, hypoxia and vascularity
-
Article
Microbubble enhancement of tumour neovascularity
-
Article
The breast
-
Article
Liver-specific imaging with SHU 563A: Diagnostic potential of a new class of ultrasound contrast media
The purpose of this study was to evaluate the imaging properties and diagnostic potential of the novel polymeric ultrasound contrast agent SHU 563 A. After i. v. injection, the agent circulates in the blood p...
-
Chapter and Conference Paper
Randomized Clinical Trial of Fibrin Sealant in Cardiac Surgery Patients Undergoing Resternotomy or Reoperation: A Multicenter Study
A multicenter study was conducted to test the efficacy and safety of fibrin sealant (FS) as a topical hemostatic agent in patients undergoing either reoperative cardiac surgery (redo) or emergency resternotomy...
-
Article
The Royal Marsden Hospital pilot tamoxifen chemoprevention trial
A pilot randomised placebo controlled trial using tamoxifen in healthy women at increased risk of develo** breast cancer, has been undertaken in order to evaluate the problems of accrual, acute symptomatic t...
-
Article
A pilot trial to evaluate the acute toxicity and feasibility of tamoxifen for prevention of breast cancer
Epidemiological and experimental evidence indicates that oestrogens are involved in the carcinogenic promotion of human breast cancer. We have undertaken a pilot trial of tamoxifen, an anti-oestrogen, compared...
-
Article
Long-term acid-induced wall extension in an in-vitro system
When frozen-thawed Avena sativa L. coleoptile and Cucumis sativa L. hypocotyl sections, under tension, are acid-treated, they undergo rapid elongation (acid-extension). The acid-extension response consists of two...
-
Article
Water relations and mechanical properties of growing cells