Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development
A Focus on Early Phase Clinical Studies
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Open AccessA narrative commentary about interoperability in medical devices and data used in diabetes therapy from an academic EU/UK/US perspective
People living with diabetes have many medical devices available to assist with disease management. A critical aspect that must be considered is how systems for continuous glucose monitoring and insulin pumps c...
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Definition, Klassifikation, Diagnostik und Differenzialdiagnostik des Diabetes mellitus: Update 2023
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Diagnose und Therapie des Typ-2-Diabetes im höheren Lebensalter
Bundesweite Schätzungen der Diabetesprävalenz in Deutschland aus Erhebungen des Robert Koch-Instituts (RKI) ergaben 7,2 % (18- bis 79-Jährige), aus RKI-Telefonbefragungen 8,9 % (18-Jährige und Ältere) bzw. auf...
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Open AccessWearable based monitoring and self-supervised contrastive learning detect clinical complications during treatment of Hematologic malignancies
Serious clinical complications (SCC; CTCAE grade ≥ 3) occur frequently in patients treated for hematological malignancies. Early diagnosis and treatment of SCC are essential to improve outcomes. Here we report...
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Definition, Klassifikation, Diagnostik und Differenzialdiagnostik des Diabetes mellitus: Update 2022
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Automated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association
A technological solution for the management of diabetes in people who require intensive insulin therapy has been sought for decades. The last 10 years have seen substantial growth in devices that can be integr...
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Open AccessSelf-Monitoring of Blood Glucose as an Integral Part in the Management of People with Type 2 Diabetes Mellitus
For decades, self-monitoring of blood glucose (SMBG) has been considered a cornerstone of adequate diabetes management. Structured SMBG can follow different monitoring patterns, and it results in improved glyc...
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Definition, Klassifikation und Diagnostik des Diabetes mellitus: Update 2021
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Definition, Klassifikation und Diagnostik des Diabetes mellitus: Update 2020
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Open AccessDiabetes management intervention studies: lessons learned from two studies
Several clinical studies investigated improvements of patient outcomes due to diabetes management interventions. However, chronic disease management is intricate with complex multifactorial behavior patterns. ...
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Definition, Klassifikation und Diagnostik des Diabetes mellitus
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Diabetes digital app technology: benefits, challenges, and recommendations. A consensus report by the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) Diabetes Technology Working Group
Digital health technology, especially digital and health applications (‘apps’), have been develo** rapidly to help people manage their diabetes. Numerous health-related apps provided on smartphones and other...
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Open AccessMeasurement Uncertainty Impacts Diagnosis of Diabetes Mellitus: Reliable Minimal Difference of Plasma Glucose Results
The diagnosis of diabetes mellitus is based on suitable cut-off values of specific biomarkers, such as the concentration of glucose in plasma. The German Diabetes Association has very recently published a clin...
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Open AccessOpen source automated insulin delivery: addressing the challenge
Do-it-yourself automated insulin delivery systems for people living with type 1 diabetes use commercially available continuous glucose sensors and insulin pumps linked by unregulated open source software. Upta...
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Glukosemessung und -kontrolle bei Patienten mit Typ-1- oder Typ-2-Diabetes
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Improving the clinical value and utility of CGM systems: issues and recommendations
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towa...
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Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group
Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even w...
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A randomised, controlled trial of self-monitoring of blood glucose in patients with type 2 diabetes receiving conventional insulin treatment
We evaluated whether self-monitoring of blood glucose (SMBG) leads to better glycaemic control (HbA1c) in patients with type 2 diabetes on conventional insulin regimens.
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A 4-h hyperglycaemic excursion induces rapid and slow changes in major electrolytes in blood in healthy human subjects
Hyperglycaemia is well known to cause reductions in plasma Na+ levels or even hyponatraemia due to an osmotically induced dilution of the interstitium and blood. It is, however, unclear whether this dilution is s...
