-
Article
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes ...
-
Article
Open AccessPlasma proteomic signatures of a direct measure of insulin sensitivity in two population cohorts
The euglycaemic–hyperinsulinaemic clamp (EIC) is the reference standard for the measurement of whole-body insulin sensitivity but is laborious and expensive to perform. We aimed to assess the incremental value...
-
Article
Automated insulin delivery: benefits, challenges, and recommendations. A Consensus Report of the Joint Diabetes Technology Working Group of the European Association for the Study of Diabetes and the American Diabetes Association
A technological solution for the management of diabetes in people who require intensive insulin therapy has been sought for decades. The last 10 years have seen substantial growth in devices that can be integr...
-
Article
Open AccessTime trends in deaths before age 50 years in people with type 1 diabetes: a nationwide analysis from Scotland 2004–2017
We aimed to examine whether crude mortality and mortality relative to the general population below 50 years of age have improved in recent years in those with type 1 diabetes.
-
Article
Open AccessComparison of serum and urinary biomarker panels with albumin/creatinine ratio in the prediction of renal function decline in type 1 diabetes
We examined whether candidate biomarkers in serum or urine can improve the prediction of renal disease progression in type 1 diabetes beyond prior eGFR, comparing their performance with urinary albumin/creatin...
-
Article
Open AccessPredicting renal disease progression in a large contemporary cohort with type 1 diabetes mellitus
The aim of this study was to provide data from a contemporary population-representative cohort on rates and predictors of renal decline in type 1 diabetes.
-
Article
Diabetes digital app technology: benefits, challenges, and recommendations. A consensus report by the European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) Diabetes Technology Working Group
Digital health technology, especially digital and health applications (‘apps’), have been develo** rapidly to help people manage their diabetes. Numerous health-related apps provided on smartphones and other...
-
Article
Open AccessPersistent C-peptide secretion in Type 1 diabetes and its relationship to the genetic architecture of diabetes
The objective of this cross-sectional study was to explore the relationship of detectable C-peptide secretion in type 1 diabetes to clinical features and to the genetic architecture of diabetes.
-
Article
Open AccessGlycaemic control trends in people with type 1 diabetes in Scotland 2004–2016
The aim of this work was to examine whether glycaemic control has improved in those with type 1 diabetes in Scotland between 2004 and 2016, and whether any trends differed by sociodemographic factors.
-
Article
Open AccessThe effect of dapagliflozin on glycaemic control and other cardiovascular disease risk factors in type 2 diabetes mellitus: a real-world observational study
Dapagliflozin, a sodium–glucose cotransporter 2 (SGLT2) inhibitor, is indicated for improving glycaemic control in type 2 diabetes mellitus. Whether its effects on HbA1c and other variables, including safety outc...
-
Chapter
Diabetes and Vascular Disease
This chapter reviews (1) current knowledge of the mechanisms underlying the pathogenesis of the vascular complications of type 1 and 2 diabetes and (2) current clinical approaches to preventing these.
-
Article
Improving the clinical value and utility of CGM systems: issues and recommendations
The first systems for continuous glucose monitoring (CGM) became available over 15 years ago. Many then believed CGM would revolutionise the use of intensive insulin therapy in diabetes; however, progress towa...
-
Article
Open AccessA new perspective on metformin therapy in type 1 diabetes
Metformin is quite frequently used off-label in type 1 diabetes to limit insulin dose requirement. Guidelines recommend that it can improve glucose control in those who are overweight and obese but evidence in...
-
Article
Open AccessRisk of acute kidney injury and survival in patients treated with Metformin: an observational cohort study
Whether metformin precipitates lactic acidosis in patients with chronic kidney disease (CKD) remains under debate. We examined whether metformin use was associated with an increased risk of acute kidney injury...
-
Article
Erratum to: Trends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013
-
Article
Open AccessTrends in type 2 diabetes incidence and mortality in Scotland between 2004 and 2013
The relative contribution of increasing incidence and declining mortality to increasing prevalence of type 2 diabetes in Scotland is unclear. Trends in incidence and mortality rates are described for type 2 di...
-
Article
Insulin pump risks and benefits: a clinical appraisal of pump safety standards, adverse event reporting and research needs. A Joint Statement of the European Association for the Study of Diabetes and the American Diabetes Association Diabetes Technology Working Group
Insulin pump therapy, also known as continuous subcutaneous insulin infusion (CSII), is an important and evolving form of insulin delivery, which is mainly used for people with type 1 diabetes. However, even w...
-
Article
Ethnicity and risk of cardiovascular disease (CVD): 4.8 year follow-up of patients with type 2 diabetes living in Scotland
Potential differences in cardiovascular risk by ethnicity remain uncertain. We evaluated the association of ethnicity with cardiovascular disease (CVD) incidence in a large cohort of people with type 2 diabete...
-
Article
Evidence-based estimation of insulin resistance
Insulin resistance is a complex phenotype. Surrogate markers based on peripheral glucose and insulin (and in some cases NEFA) concentrations can provide, at best, moderate approximations to direct physiologica...
-
Article
Open AccessThe cardiovascular safety of incretin-based therapies: a review of the evidence
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality in people with diabetes and therefore managing cardiovascular (CV) risk is a critical component of diabetes care. As incretin-based th...
