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Open AccessEstimated glomerular filtration rate in observational and interventional studies in chronic kidney disease
Estimated glomerular filtration rate is considered the principal measure of kidney function and, together with albuminuria, is a relevant prognostic factor for the development of end-stage kidney disease. Due ...
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Article
Open AccessRecommendations for the management of hyperkalemia in patients receiving renin–angiotensin–aldosterone system inhibitors
Hyperkalemia is common in clinical practice and can be caused by medications used to treat cardiovascular diseases, particularly renin–angiotensin–aldosterone system inhibitors (RAASis). This narrative review ...
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Article
Resistance to erythropoiesis stimulating agents in a dialysis patient after kidney graft failure
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Sodium-glucose cotransporter-2 inhibition in a CKD patient with severe heart failure treated by high-dose diuretics and peritoneal ultrafiltration: lesson for the clinical nephrologist
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Article
Nothing is less green than war
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Open AccessSafety of Roxadustat Versus Erythropoiesis-Stimulating Agents in Patients with Anemia of Non-dialysis-Dependent or Incident-to-Dialysis Chronic Kidney Disease: Pooled Analysis of Four Phase 3 Studies
This study was conducted to elucidate the safety of roxadustat, an oral medication, in patients with non-dialysis-dependent (NDD) or incident dialysis dialysis-dependent (ID-DD) chronic kidney disease (CKD).
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Open AccessThe number of risk factors not at target is associated with cardiovascular risk in a type 2 diabetic population with albuminuria in primary cardiovascular prevention. Post-hoc analysis of the NID-2 trial
Nephropathy in Diabetes type 2 (NID-2) study is an open-label cluster randomized clinical trial that demonstrated that multifactorial intensive treatment reduces Major Adverse Cardiac Events (MACEs) and overal...
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Changes over time in ambulatory blood pressure and cardiac parameters predict cardiovascular outcome of patients with CKD and low cardiovascular morbidity
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Open Access“The Disease Awareness Innovation Network” for chronic kidney disease identification in general practice
The “awareness gap” and the under-recognition of chronic kidney disease (CKD) by general practitioners (GPs) is well documented. We set a framework to evaluate the impact in primary care of targeted training a...
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Article
Evolving Strategies in the Treatment of Anaemia in Chronic Kidney Disease: The HIF-Prolyl Hydroxylase Inhibitors
Chronic kidney disease (CKD) affects approximately 10% of the worldwide population; anaemia is a frequent complication. Inadequate erythropoietin production and absolute or functional iron deficiency are the m...
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Antiproteinuric effect of paricalcitol in kidney transplant recipients with severe proteinuria: a prospective cohort study
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Open AccessCan SGLT2 inhibitors answer unmet therapeutic needs in chronic kidney disease?
Chronic kidney disease (CKD) is a global health problem, affecting more than 850 million people worldwide. The number of patients receiving renal replacement therapy (dialysis or renal transplantation) has inc...
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15-year-change of phenotype and prognosis in non-dialysis CKD patients referred to a nephrology clinic
Changes over time of phenotype and prognosis in CKD patients starting nephrology care are undefined. This information is critical to correctly plan and optimize healthcare resources and clinical management in ...
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Article
Open AccessSmoking habit as a risk amplifier in chronic kidney disease patients
Several studies showed the association between non-traditional risk factors [proteinuria and estimated Glomerular Filtration Rate (eGFR)] and cardiovascular (CV) and renal outcomes. Nevertheless, the etiologic...
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Article
Open AccessEfficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease
Multiple modifiable risk factors for late complications in patients with diabetic kidney disease (DKD), including hyperglycemia, hypertension and dyslipidemia, increase the risk of a poor outcome. DKD is assoc...
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Highlights from the 60th national meeting of the Italian Society of Nephrology: celebrating the role of the nephrologist
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Open AccessManagement of dyslipidaemia in patients with chronic kidney disease: a position paper endorsed by the Italian Society of Nephrology
Chronic kidney disease (CKD) represents a major public health issue worldwide and entails a high burden of cardiovascular events and mortality. Dyslipidaemia is common in patients with CKD and it is characteri...
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Open AccessPreventing major adverse cardiovascular events by SGLT-2 inhibition in patients with type 2 diabetes: the role of kidney
Cardiovascular outcome trials (CVOTs) have demonstrated a significant reduction of major adverse cardiovascular events (MACE) in patients with type 2 diabetes (T2D) treated by SGLT-2 inhibitors. This holds tru...
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Article
Sodium toxicity in peritoneal dialysis: mechanisms and “solutions”
The major trials in peritoneal dialysis (PD) have demonstrated that increasing peritoneal clearance of small solutes is not associated with any advantage on survival, whereas sodium and fluid overload heralds ...
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Article
Open AccessDiabetic kidney disease: new clinical and therapeutic issues. Joint position statement of the Italian Diabetes Society and the Italian Society of Nephrology on “The natural history of diabetic kidney disease and treatment of hyperglycemia in patients with type 2 diabetes and impaired renal function”
This joint document of the Italian Diabetes Society and the Italian Society of Nephrology reviews the natural history of diabetic kidney disease (DKD) in the light of the recent epidemiological literature and ...
