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Open AccessKEA-1010, a ketamine ester analogue, retains analgesic and sedative potency but is devoid of Psychomimetic effects
Ketamine, a widely used anaesthetic and analgesic agent, is known to improve the analgesic efficacy of opioids and to attenuate central sensitisation and opioid-induced hyperalgesia. Clinical use is, however, ...
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Article
Open AccessModulation of frontal EEG alpha oscillations during maintenance and emergence phases of general anaesthesia to improve early neurocognitive recovery in older patients: protocol for a randomised controlled trial
Postoperative delirium may manifest in the immediate post-anaesthesia care period. Such episodes appear to be predictive of further episodes of inpatient delirium and associated adverse outcomes. Frontal elect...
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Anesthesia-Induced State Transitions in Neuronal Populations
It is a simple observation that the function of the central nervous system changes abruptly at certain critical brain concentrations of the anesthetic drug. This can be viewed as analogous to “state transition...
