-
Article
A multi-parameter-induced activation of gas therapeutic platform to remarkably amplify photodynamic therapy efficacy
Gas therapy (GT) combined with photodynamic therapy (PDT) is an effective strategy to compensate for the PDT limitation caused by the hypoxic tumor microenvironment, which can greatly improve PDT efficacy. The...
-
Article
Oncofetal SNRPE promotes HCC tumorigenesis by regulating the FGFR4 expression through alternative splicing
Due to insufficient knowledge about key molecular events, Hepatocellular carcinoma (HCC) lacks effective treatment targets. Spliceosome-related genes were significantly altered in HCC. Oncofetal proteins are i...
-
Article
Open AccessComplexity of many-body interactions in transition metals via machine-learned force fields from the TM23 data set
This work examines challenges associated with the accuracy of machine-learned force fields (MLFFs) for bulk solid and liquid phases of d-block elements. In exhaustive detail, we contrast the performance of force,...
-
Article
Open AccessLow-index mesoscopic surface reconstructions of Au surfaces using Bayesian force fields
Metal surfaces have long been known to reconstruct, significantly influencing their structural and catalytic properties. Many key mechanistic aspects of these subtle transformations remain poorly understood du...
-
Article
Cretaceous integrative stratigraphy, biotas, and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas
The Cretaceous Period is a vital time interval in deciphering the evolutionary history of the Neo-Tethys Ocean and the convergence of different plates and blocks across the Qinghai-Tibetan Plateau. A detailed ...
-
Article
Correlation of endolymphatic hydrops and perilymphatic enhancement with the clinical features of Ménière’s disease
To use three-dimensional real inversion recovery (3D-real IR) MRI to investigate correlations between endolymphatic hydrops (EH) grades or the degree of perilymphatic enhancement (PE) and clinical features of ...
-
Chapter and Conference Paper
Does AI for Science Need Another ImageNet or Totally Different Benchmarks? A Case Study of Machine Learning Force Fields
AI for science (AI4S) is an emerging research field that aims to enhance the accuracy and speed of scientific computing tasks using machine learning methods. Traditional AI benchmarking methods struggle to ada...
-
Article
Open AccessMRI can help differentiate Ménière’s disease from other menieriform diseases
It is difficult to distinguish other pathologies mimicking Ménière’s disease (MD) clinically. This study aims to investigate the differences of imaging findings and features between MD and other menieriform di...
-
Article
The value of integration of bone scan and targeted SPECT/CT in diagnosis of primary hyperparathyroidism with multiple bone brown tumor
Although parathyroid bone disease is rarely seen nowadays, skeletal manifestation can be the first sign of hyperparathyroidism (HPT) in some clinical practice. Nevertheless, the diagnosis of HPT is often overl...
-
Article
Open AccessUse of routine healthcare data in randomised implementation trials: a methodological mixed-methods systematic review
Routine data are increasingly used in randomised controlled trials evaluating healthcare interventions. They can aid participant identification, outcome assessment, and intervention delivery. Randomised implem...
-
Article
Comparison of PD-L1 expression and MMR status between primary and matched metastatic lesions in patients with cervical cancer
Programmed death-ligand 1 (PD-L1) and DNA mismatch repair (MMR) are considered predictive biomarkers for immunotherapy in cervical cancer. However, their expression in primary tumors and metastases does not al...
-
Article
Improving diagnostic accuracy for probable and definite Ménière’s disease using magnetic resonance imaging
To determine whether magnetic resonance imaging (MRI) can improve diagnostic accuracy for definite and probable Ménière’s disease (MD) based on perilymphatic enhancement (PE) and endolymphatic hydrops (EH).
-
Article
Activation of cDCs and iNKT cells contributes to triptolide-induced hepatotoxicity via STING signaling pathway and endoplasmic reticulum stress
Triptolide (TP) exhibits therapeutic potential against multiple diseases. However, its application in clinics is limited by TP-induced hepatoxicity. TP can activate invariant natural killer T (iNKT) cells in t...
-
Article
The long-term outcomes of clinical responders to neoadjuvant chemotherapy followed by radical surgery in locally advanced cervical cancer
To compare the long-term oncological outcome of neoadjuvant chemotherapy before radical surgery (NCRS) and definitive chemoradiotherapy (DR) for stage IB2 and IIA2 cervical squamous cell carcinoma.
-
Article
A dual-modality hydrogen sulfide-specific probe integrating chemiluminescence with NIR fluorescence for targeted cancer imaging
Taking apart in numerous physiological and pathological activities, hydrogen sulfide (H2S) has been selected as an excellent target spot for the early diagnosis of cancer. So far, there are many mature probes tha...
-
Article
Open AccessRelationship between preoperative red blood cell distribution width and postoperative pneumonia in elderly patients with hip fracture: a retrospective cohort study
The relationship between the preoperative red blood cell distribution width and postoperative pneumonia in elderly patients with hip fractures remains unclear. This study investigated whether the preoperative ...
-
Article
Open AccessDeficiency of Perry syndrome-associated p150Glued in midbrain dopaminergic neurons leads to progressive neurodegeneration and endoplasmic reticulum abnormalities
Multiple missense mutations in p150Glued are linked to Perry syndrome (PS), a rare neurodegenerative disease pathologically characterized by loss of nigral dopaminergic (DAergic) neurons. Here we generated p150Gl...
-
Article
Enhancement of Strength and Plasticity by Nanoprecipitation Strengthening and Stacking Fault Deformation in a High Entropy Alloy
Precipitation strengthening can effectively improve the strength of high entropy alloys (HEAs), but usually severely reduces the ductility. In this study, a new interstitial carbon-doped HEA with a nominal com...
-
Article
Impact of orthogonal transformation for factors on model performance in landslide susceptibility
Considering the correlation among the conditioning factors, this study explores the impact of the orthogonal transformation for factors on model performance, with the LR model. Landslide inventory and factor t...
-
Article
Open AccessEffects of preoperative oral enzyme-hydrolyzed rice flour solution on gastric emptying and insulin resistance in patients undergoing laparoscopic cholecystectomy: a prospective randomized controlled trial
The effect of preoperative oral carbohydrates (POC) on insulin resistance (IR) of laparoscopic cholecystectomy (LC) remains debatable. Enzyme-hydrolyzed rice flour (EHR) is a kind of water-soluble micromolecul...
