27 Result(s)

Article

Whole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation

Chinese indigenous sheep are valuable resources with unique features and characteristics. They are distributed across regions with different climates in mainland China; however, few reports have analyzed the e...

Meilin **, Huihua Wang, Gang Liu, Jian Lu, Zehu Yuan… in Genetics Selection Evolution (2024)

Article

Preparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles

This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the resulting Ginsenoside Rb1-PLGA Nanoparticles (GRb1@PLGA@NPs). GRb...

Lixin Du, Huiling Lu, Yifei **ao, Zhihua Guo, Ya Li in Scientific Reports (2023)

Article

Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?

Mei Qiu, Fangjun Luo, Lixin Du in Endocrine (2023)

Article

GLP1RAs vs SGLT2is were associated with lower risk of major adverse limb events and similar risks of heart failure hospitalisation and stroke?

Lixin Du, Pan Wang, Hongwei Chen, Yu Zhang, Jianlan Ma in Diabetologia (2023)

Article

A comparative study between deep learning and radiomics models in grading liver tumors using hepatobiliary phase contrast-enhanced MR images

To compare a deep learning model with a radiomics model in differentiating high-grade (LR-3, LR-4, LR-5) liver imaging reporting and data system (LI-RADS) liver tumors from low-grade (LR-1, LR-2) LI-RADS tumor...

Lixin Du, Jianpeng Yuan, Meng Gan, Zhigang Li, Pan Wang, Zujun Hou… in BMC Medical Imaging (2022)

Article

Correction to: Does evidence from RCTs suggest: SGLT2 inhibitors could not reduce myocardial infarction and stroke?

Lixin Du, Zhigang Li, Peng Lan, Huayu Huang… in European Journal of Clinical Pharmacology (2022)

Article

Genome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread

The fall webworm Hyphantria cunea is an invasive and polyphagous defoliator pest that feeds on nearly any type of deciduous tree worldwide. The silk web of H. cunea aids its aggregating behavior, provides thermal...

Qi Chen, Hanbo Zhao, Ming Wen, Jiaxin Li, Haifeng Zhou, Jiatong Wang… in BMC Genomics (2020)

Article

Genome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays

Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han sheep, Altay sheep, and Tib...

Caiye Zhu, Hongying Fan, Zehu Yuan, Shi** Hu, … in Scientific Reports (2016)

Article

Genome-wide analysis reveals adaptation to high altitudes in Tibetan sheep

Tibetan sheep have lived on the Tibetan Plateau for thousands of years; however, the process and consequences of adaptation to this extreme environment have not been elucidated for important livestock such as ...

Caihong Wei, Huihua Wang, Gang Liu, Fu** Zhao, James W. Kijas… in Scientific Reports (2016)

Article

Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system

Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made rela...

Mingming Wu, Caihong Wei, Zhengxing Lian, Ruizao Liu, Caiye Zhu… in Scientific Reports (2016)

Article

DNA methylation Landscape of body size variation in sheep

Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays...

Jiaxue Cao, Caihong Wei, Dongming Liu, Huihua Wang, Mingming Wu… in Scientific Reports (2015)

Article

Detection of selection signatures in dairy and beef cattle using high-density genomic information

Artificial selection for economically important traits in cattle is expected to have left distinctive selection signatures on the genome. Access to high-density genotypes facilitates the accurate identificatio...

Fu** Zhao, Sinead McParland, Francis Kearney, Lixin Du… in Genetics Selection Evolution (2015)

Article

Genome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds

Traditionally, Chinese indigenous sheep were classified geographically and morphologically into three groups: Mongolian, Kazakh and Tibetan. Herein, we aimed to evaluate the population structure and genome sel...

Caihong Wei, Huihua Wang, Gang Liu, Mingming Wu, Jiaxve Cao, Zhen Liu… in BMC Genomics (2015)

Article

AAV2-mediated follistatin overexpression induces ovine primary myoblasts proliferation

Follistatin (FST) has been shown to bind to some TGF-β family members and can function as a potent myostatin (MSTN) antagonist. Recent studies have revealed that over-expression of FST by adeno-associated viru...

Mahmood Nazari, Fatemeh Salabi, Li Zhang, Fu** Zhao, Caihong Wei… in BMC Biotechnology (2014)

Article

Comparison of single-trait and multiple-trait genomic prediction models

In this study, a single-trait genomic model (STGM) is compared with a multiple-trait genomic model (MTGM) for genomic prediction using conventional estimated breeding values (EBVs) calculated using a conventio...

Gang Guo, Fu** Zhao, Yachun Wang, Yuan Zhang, Lixin Du, Guosheng Su in BMC Genetics (2014)