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Article
A small-molecule activation mechanism that directly opens the KCNQ2 channel
Pharmacological activation of voltage-gated ion channels by ligands serves as the basis for therapy and mainly involves a classic gating mechanism that augments the native voltage-dependent open probability. T...
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Article
ZMNet: feature fusion and semantic boundary supervision for real-time semantic segmentation
Feature fusion module is an essential component of real-time semantic segmentation networks to bridge the semantic gap among different feature layers. However, many networks are inefficient in multi-level feat...
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Article
Open AccessIdentification of a novel monocyte/macrophage-related gene signature for predicting survival and immune response in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematological tumor with poor immunotherapy effect. This study was to develop a monocyte/macrophage-related prognostic risk score (MMrisk) and identify new thera...
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Article
Open AccessChiral dinitrogen ligand enabled asymmetric Pd/norbornene cooperative catalysis toward the assembly of C–N axially chiral scaffolds
C − N axially chiral compounds have recently attracted significant interest among synthetic chemistry community due to their widespread application in pharmaceuticals, advanced materials and organic synthesis....
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Article
An effective fault localization approach for Verilog based on enhanced contexts
The HDL research community recognizes the pivotal role of bug localization in the debugging workflow, offering substantial relief to developers. This paper introduces ContextHD, a robust bug localization metho...
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Article
ACE2 Expressed on Myeloid Cells Alleviates Sepsis-Induced Acute Liver Injury via the Ang-(1–7)–Mas Receptor Axis
Sepsis-induced acute liver injury (ALI) is common in intensive care units. Angiotensin-converting enzyme 2 (ACE2) plays a vital role in hepatic fibrosis and steatosis; however, its role in sepsis-induced ALI r...
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Article
Neglected function of gastrin to reduce feeding in Siberian sturgeon (Acipenser baerii) via cholecystokinin receptor B
Gastrin is an important intragastrointestinal hormone, but reports on its regulation of feeding behavior in fish are still scarce. This study aimed to determine the feeding regulatory function of gastrin in st...
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Article
Open AccessMRI-based vertebral bone quality score as a novel bone status marker of patients with adolescent idiopathic scoliosis
To investigate the application of MRI-based vertebral bone quality (VBQ) score in assessing bone mineral density (BMD) for patients with adolescent idiopathic scoliosis (AIS). We reviewed the data of AIS patie...
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Article
Surgical procedures and techniques in robot-assisted uterine artery-preserving radical trachelectomy
The aim of the study was to study robotic cervical radical trachelectomy, aimed at standardizing and optimizing surgical procedures, thereby facilitating the learning process. All surgical procedures were base...
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Article
Open AccessCharacterization of tryptanthrin as an antibacterial reagent inhibiting Vibrio splendidus
Isolates of Vibrio splendidus are ubiquitously presented in various marine environments, and they can infect diverse marine culture animals, leading to high mortality and economic loss. Therefore, a control strat...
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Article
Open AccessTspan protein family: focusing on the occurrence, progression, and treatment of cancer
The Tetraspanins (Tspan) protein family, also known as the tetraspanin family, contains 33 family members that interact with other protein molecules such as integrins, adhesion molecules, and T cell receptors ...
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Article
Open AccessSCB-YOLOv5: a lightweight intelligent detection model for athletes’ normative movements
Intelligent detection of athlete behavior is beneficial for guiding sports instruction. Existing mature target detection algorithms provide significant support for this task. However, large-scale target detect...
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Article
Open AccessFBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation
Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although the E3 ubiquitin ligase FBXL8 is a key regulator in the cell cycle, cell proliferation, and ...
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Article
Open AccessEfficacy and safety of lenalidomide in the treatment of B-cell non-Hodgkin lymphoma
The combination of rituximab and chemotherapy is a first-line treatment for patients with B-cell non-Hodgkin lymphoma. Lenalidomide is an immunomodulatory drug that has shown promising properties and activity ...
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Article
Open AccessSpatiotemporal transcriptomic changes of human ovarian aging and the regulatory role of FOXP1
Limited understanding exists regarding how aging impacts the cellular and molecular aspects of the human ovary. This study combines single-cell RNA sequencing and spatial transcriptomics to systematically char...
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Article
Open AccessUrocortin-1 promotes colorectal cancer cell migration and proliferation and inhibits apoptosis via inhibition of the p53 signaling pathway
To investigate the effect of urocortin-1 (UCN-1) on growth, migration, and apoptosis in colorectal cancer (CRC) in vivo and vitro and the mechanism by which UCN-1 modulates CRC cells in vitro.
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Article
ACE2 Rescues Sepsis-Associated Encephalopathy by Reducing Inflammation, Oxidative Stress, and Neuronal Apoptosis via the Nrf2/Sestrin2 Signaling Pathway
Neuroinflammation and oxidative stress contribute to the progression of sepsis-associated encephalopathy (SAE). Angiotensin-converting enzyme 2 (ACE2) is considered to be a neuroprotective factor due to its an...
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Article
SOX21-AS1 Augmented Cervical Cancer Growth by Triggering FZD3 to Activate the Wnt/β-Catenin Signaling Pathway
Long non-coding RNA (LncRNA) SOX21-AS1 has been reported that it plays an important role in biological processes of several cancers. However, how it functions in cervical cancer (CC) still remain unclear. This...
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Article
Drp1: Focus on Diseases Triggered by the Mitochondrial Pathway
Drp1 (Dynamin-Related Protein 1) is a cytoplasmic GTPase protein encoded by the DNM1L gene that influences mitochondrial dynamics by mediating mitochondrial fission processes. Drp1 has been demonstrated to pla...
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Article
Examining the metal futures price discovery in China from multi-scale time
Metal mineral resources are important raw materials in industrial production, and metal as an important object in the futures market, its discovery function is an important sign to measure the level of market ...
