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Open AccessWhole-genome resequencing of Chinese indigenous sheep provides insight into the genetic basis underlying climate adaptation
Chinese indigenous sheep are valuable resources with unique features and characteristics. They are distributed across regions with different climates in mainland China; however, few reports have analyzed the e...
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Article
Open AccessPreparation, characterization and in vivo pharmacokinetic study of ginsenoside Rb1-PLGA nanoparticles
This study aimed to construct a Ginsenoside Rb1-PLGA nano drug delivery system, optimize its preparation process, characterize and evaluate the resulting Ginsenoside Rb1-PLGA Nanoparticles (GRb1@PLGA@NPs). GRb...
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Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?
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GLP1RAs vs SGLT2is were associated with lower risk of major adverse limb events and similar risks of heart failure hospitalisation and stroke?
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Open AccessA comparative study between deep learning and radiomics models in grading liver tumors using hepatobiliary phase contrast-enhanced MR images
To compare a deep learning model with a radiomics model in differentiating high-grade (LR-3, LR-4, LR-5) liver imaging reporting and data system (LI-RADS) liver tumors from low-grade (LR-1, LR-2) LI-RADS tumor...
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Correction to: Does evidence from RCTs suggest: SGLT2 inhibitors could not reduce myocardial infarction and stroke?
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Open AccessGenome of the webworm Hyphantria cunea unveils genetic adaptations supporting its rapid invasion and spread
The fall webworm Hyphantria cunea is an invasive and polyphagous defoliator pest that feeds on nearly any type of deciduous tree worldwide. The silk web of H. cunea aids its aggregating behavior, provides thermal...
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Open AccessGenome-wide detection of CNVs in Chinese indigenous sheep with different types of tails using ovine high-density 600K SNP arrays
Chinese indigenous sheep can be classified into three types based on tail morphology: fat-tailed, fat-rumped, and thin-tailed sheep, of which the typical breeds are large-tailed Han sheep, Altay sheep, and Tib...
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Open AccessGenome-wide analysis reveals adaptation to high altitudes in Tibetan sheep
Tibetan sheep have lived on the Tibetan Plateau for thousands of years; however, the process and consequences of adaptation to this extreme environment have not been elucidated for important livestock such as ...
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Open AccessRosa26-targeted sheep gene knock-in via CRISPR-Cas9 system
Recent advances in our ability to design DNA binding factors with specificity for desired sequences have resulted in a revolution in genetic engineering, enabling directed changes to the genome to be made rela...
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Open AccessDNA methylation Landscape of body size variation in sheep
Sub-populations of Chinese Mongolian sheep exhibit significant variance in body mass. In the present study, we sequenced the whole genome DNA methylation in these breeds to detect whether DNA methylation plays...
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Open AccessDetection of selection signatures in dairy and beef cattle using high-density genomic information
Artificial selection for economically important traits in cattle is expected to have left distinctive selection signatures on the genome. Access to high-density genotypes facilitates the accurate identificatio...
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Open AccessGenome-wide analysis reveals population structure and selection in Chinese indigenous sheep breeds
Traditionally, Chinese indigenous sheep were classified geographically and morphologically into three groups: Mongolian, Kazakh and Tibetan. Herein, we aimed to evaluate the population structure and genome sel...
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Open AccessAAV2-mediated follistatin overexpression induces ovine primary myoblasts proliferation
Follistatin (FST) has been shown to bind to some TGF-β family members and can function as a potent myostatin (MSTN) antagonist. Recent studies have revealed that over-expression of FST by adeno-associated viru...
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Open AccessComparison of single-trait and multiple-trait genomic prediction models
In this study, a single-trait genomic model (STGM) is compared with a multiple-trait genomic model (MTGM) for genomic prediction using conventional estimated breeding values (EBVs) calculated using a conventio...
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Open AccessAnalysis of copy number variations in the sheep genome using 50K SNP BeadChip array
In recent years, genome-wide association studies have successfully uncovered single-nucleotide polymorphisms (SNPs) associated with complex traits such as diseases and quantitative phenotypes. These variations...
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Open AccessHistological and transcriptome-wide level characteristics of fetal myofiber hyperplasia during the second half of gestation in Texel and Ujumqin sheep
Whether myofibers increase with a pulsed-wave mode at particular developmental stages or whether they augment evenly across developmental stages in large mammals is unclear. Additionally, the molecular mechani...
