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Article
Open AccessSerum IL-6, sAXL, and YKL-40 as systemic correlates of reduced brain structure and function in Alzheimer’s disease: results from the DELCODE study
Neuroinflammation constitutes a pathological hallmark of Alzheimer’s disease (AD). Still, it remains unresolved if peripheral inflammatory markers can be utilized for research purposes similar to blood-based b...
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Article
Open AccessMedin co-aggregates with vascular amyloid-β in Alzheimer’s disease
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently kno...
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Article
Open AccessExperimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae
Brain Aβ deposition is a key early event in the pathogenesis of Alzheimer´s disease (AD), but the long presymptomatic phase and poor correlation between Aβ deposition and clinical symptoms remain puzzling. To ...
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Article
Open AccessCSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles
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Article
Open AccessCerebrospinal fluid cytokine levels are associated with macrophage infiltration into tumor tissues of glioma patients
Diffuse gliomas are the most common malignant tumors of the central nervous system with poor treatment efficacy. Infiltration of immune cells into tumors during immunosurveillance is observed in multiple tumor...
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Article
Open AccessMicroglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...
