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Article
Open AccessMicroglial inclusions and neurofilament light chain release follow neuronal α-synuclein lesions in long-term brain slice cultures
Proteopathic brain lesions are a hallmark of many age-related neurodegenerative diseases including synucleinopathies and develop at least a decade before the onset of clinical symptoms. Thus, understanding of ...
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Article
Open AccessProminent microglial inclusions in transgenic mouse models of α-synucleinopathy that are distinct from neuronal lesions
Alpha-synucleinopathies are a group of progressive neurodegenerative disorders, characterized by intracellular deposits of aggregated α-synuclein (αS). The clinical heterogeneity of these diseases is thought t...
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Article
Open AccessOlaparib significantly delays photoreceptor loss in a model for hereditary retinal degeneration
The enzyme poly-ADP-ribose-polymerase (PARP) mediates DNA-repair and rearrangements of the nuclear chromatin. Generally, PARP activity is thought to promote cell survival and in recent years a number of PARP i...
